Immunotherapy to deal with most cancers is now a longtime scientific strategy. Immunotherapy may be utilized systemically, as accomplished with checkpoint blockade antibodies, but it surely can be injected straight into recognized tumors, in a method of in situ vaccination (ISV). ISV is designed to stimulate a robust native antitumor immune response involving each innate and adaptive immune cells, and via this generate a systemic antitumor immune response against metastatic tumors. Quite a lot of ISVs have been utilized to generate an immunostimulatory tumor microenvironment (TME).
These embody attenuated microorganisms, recombinant proteins, small molecules, bodily disruptors of TME (alternating magnetic and centered ultrasound heating, photothermal remedy, and radiotherapy), and extra not too long ago nanoparticles (NPs). NPs are engaging and distinctive since they will load a number of medicine or different reagents to affect immune and most cancers cell capabilities in the TME, affording a novel alternative to stimulate antitumor immunity. Here, we describe the NP-ISV therapeutic mechanisms, assessment chemically synthesized NPs (i.e., liposomes, polymeric, chitosan-based, inorganic NPs, and so forth.), biologically derived NPs (virus and bacteria-based NPs), and energy-activated NP-ISVs in the context of their use as native ISV. Data means that NP-ISVs can improve outcomes of immunotherapeutic regimens together with these using tumor hyperthermia and checkpoint blockade therapies.
The complement system is a conserved element of innate immunity that fulfills numerous roles in protection and homeostasis. Inappropriate activation of complement contributes to many inflammatory illnesses, nonetheless, which has led to a renewed emphasis on improvement of therapeutic complement inhibitors. Activation of complement element C3 is required for amplification of complement and is achieved via two multisubunit proteases known as C3 convertases. Of these, the choice pathway (AP) C3 convertase is accountable for a majority of the C3 activation merchandise in vivo, which renders it a gorgeous goal for inhibitor discovery.
In this research, we report the identification and characterization of two associated sluggish off-rate modified DNA aptamers (SOMAmer) reagents that inhibit formation of the AP C3 convertase by binding to the proprotease, issue B (FB). These aptamers, often known as SL1102 (31 bases) and SL1103 (29 bases), comprise uniform substitutions of 5-(N-2-naphthylethylcarboxyamide)-2′-deoxyuridine for deoxythymidine. SL1102 and SL1103 bind FB with Ok d values of 49 and 88 pM, respectively, and inhibit activation of C3 and lysis of rabbit erythrocytes beneath AP-specific circumstances.
Cocrystal buildings of SL1102 (3.four Å) and SL1103 (3.1 Å) certain to human FB revealed that SL1102 and SL1103 acknowledge a web site on the juncture of the CCP1, CCP3, and vWF domains of FB. Consistent with these buildings and beforehand revealed data, these aptamers inhibited FB binding to C3b and blocked formation of the AP C3 convertase. Together, these outcomes show potent AP inhibition by modified DNA aptamers and increase the pipeline of FB-binding molecules with favorable pharmacologic properties.
Higher-Order Structure Characterization of NKG2A/CD94 Protein Complex and Anti-NKG2A Antibody Binding Epitopes by Mass Spectrometry-Based Protein Footprinting Strategies
NK group 2 member A (NKG2A), an immune checkpoint inhibitor, is an rising therapeutic goal in immuno-oncology. NKG2A kinds a heterodimer with CD94 on the cell floor of NK and a subset of T cells and acknowledges the nonclassical human leukocyte antigen (HLA-E) in people. Therapeutic blocking antibodies that block the ligation between HLA-E and NKG2A/CD94 have been proven to boost antitumor immunity in mice and people. In this research, we illustrate the sensible utilities of mass spectrometry (MS)-based protein footprinting in areas from reagent characterization to antibody epitope mapping.
Hydrogen/deuterium trade mass spectrometry (HDX-MS) in the higher-order construction characterization of NKG2A in complicated with CD94 offers novel insights into the conformational dynamics of NKG2A/CD94 heterodimer. To absolutely perceive antibody/goal interactions, we employed complementary protein footprinting strategies, together with HDX-MS and quick photochemical oxidation of proteins (FPOP)-MS, to find out the binding epitopes of therapeutic monoclonal antibodies focusing on NKG2A. Such a mix strategy offers molecular insights into the binding mechanisms of antibodies to NKG2A with excessive specificity, demonstrating the blockade of NKG2A/HLA-E interplay.
Generation of Human iPSCs by Protein Reprogramming and Stimulation of TLR3 Signaling
The discovery of induced pluripotent stem cells (iPSCs) permits for institution of human embryonic stem-like cells from numerous grownup human somatic cells (e.g., fibroblasts), with out the necessity for destruction of human embryos. This offers an unprecedented alternative the place patient-specific iPSCs may be subsequently differentiated to many cell varieties, e.g., cardiac cells and neurons, in order that we will use these iPSC-derived cells to check patient-specific illness mechanisms and conduct drug testing and screening. Critically, these cells have limitless therapeutic potentials, and there are lots of ongoing scientific trials to analyze the regenerative potentials of those iPSC-derivatives in people. However, the standard iPSC reprogramming strategies have drawback of insertional mutagenesis due to use of the integrating viral vectors.
 Recombinant Human Transcription Factor-A |
|
7-06637 |
CHI Scientific |
1µg |
Ask for price |
Recombinant Human Transcription Factor-A |
|
7-06638 |
CHI Scientific |
5µg |
Ask for price |
Recombinant Human Transcription Factor-A |
|
7-06639 |
CHI Scientific |
50µg |
Ask for price |
 IRGM Immunity-Related GTPase Family, M Human Recombinant Protein |
|
PROTA1A4Y4 |
BosterBio |
Regular: 20ug |
EUR 317 |
|
Description: IRGM Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 180 amino acids (23-181) and having a molecular mass of 20.1 kDa. IRGM is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
) Recombinant Transcription Factor A, Mitochondrial (TFAM) |
|
4-RPH050Hu01 |
Cloud-Clone |
-
EUR 508.58
-
EUR 239.00
-
EUR 1632.16
-
EUR 610.72
-
EUR 1121.44
-
EUR 403.00
-
EUR 3930.40
|
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100 ug
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10ug
-
1 mg
-
200 ug
-
500 ug
-
50ug
-
5 mg
|
- Uniprot ID: Q00059
- Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
- Form: Freeze-dried powder
- Predicted Molecular Mass (KD): 51.4kDa
- Isoelectric Point: Inquire
|
|
Description: Recombinant Human Transcription Factor A, Mitochondrial expressed in: E.coli |
Recombinant Transcription Factor A, Mitochondrial (TFAM) |
|
4-RPH050Mu01 |
Cloud-Clone |
-
EUR 583.84
-
EUR 259.00
-
EUR 1914.40
-
EUR 704.80
-
EUR 1309.60
-
EUR 454.00
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EUR 4636.00
|
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100 ug
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10ug
-
1 mg
-
200 ug
-
500 ug
-
50ug
-
5 mg
|
- Uniprot ID: P40630
- Buffer composition: 100mMNaHCO3, 500mMNaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
- Form: Freeze-dried powder
- Predicted Molecular Mass (KD): 53.6kDa
- Isoelectric Point: 9.1
|
|
Description: Recombinant Mouse Transcription Factor A, Mitochondrial expressed in: E.coli |
Recombinant Transcription Factor A, Mitochondrial (TFAM) |
|
4-RPH050Ra01 |
Cloud-Clone |
-
EUR 592.80
-
EUR 262.00
-
EUR 1948.00
-
EUR 716.00
-
EUR 1332.00
-
EUR 460.00
-
EUR 4720.00
|
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100 ug
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10ug
-
1 mg
-
200 ug
-
500 ug
-
50ug
-
5 mg
|
- Uniprot ID: Q91ZW1
- Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
- Form: Freeze-dried powder
- Predicted Molecular Mass (KD): 50.4kDa
- Isoelectric Point: Inquire
|
|
Description: Recombinant Rat Transcription Factor A, Mitochondrial expressed in: E.coli |
) Recombinant Nuclear Factor I/A (NFIA) |
|
4-RPC655Hu01 |
Cloud-Clone |
-
EUR 458.40
-
EUR 226.00
-
EUR 1444.00
-
EUR 548.00
-
EUR 996.00
-
EUR 370.00
-
EUR 3460.00
|
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100 ug
-
10ug
-
1 mg
-
200 ug
-
500 ug
-
50ug
-
5 mg
|
- Uniprot ID: Q12857
- Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
- Form: Freeze-dried powder
- Predicted Molecular Mass (KD): 20.8kDa
- Isoelectric Point: Inquire
|
|
Description: Recombinant Human Nuclear Factor I/A expressed in: E.coli |
 Antibody) Immunity Related GTPase M (IRGM) Antibody |
|
abx412110-01mg |
Abbexa |
0.1 mg |
EUR 537 |
|
|
) Recombinant Human Vascular Endothelial Growth Factor (a. a. 165) |
|
DAG304 |
Creative Diagnostics |
10ug |
EUR 748 |
) Recombinant Escherichia coli Colicin-Ia immunity Protein (aa 1-111) |
|
VAng-Lsx02230-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Escherichia coli Colicin-Ia immunity protein, recombinant protein. |
) Recombinant Escherichia coli Colicin-Ia immunity Protein (aa 1-32) |
|
VAng-Lsx02231-1mgEcoli |
Creative Biolabs |
1 mg (E. coli) |
EUR 2938 |
|
Description: Escherichia coli Colicin-Ia immunity protein (aa 1-32), recombinant protein. |
Recombinant Escherichia coli Colicin-Ia immunity Protein (aa 1-32) |
|
VAng-Lsx02231-500gEcoli |
Creative Biolabs |
500 µg (E. coli) |
EUR 2223 |
|
Description: Escherichia coli Colicin-Ia immunity protein (aa 1-32), recombinant protein. |
) Recombinant Escherichia coli Colicin-Ib immunity Protein (aa 1-115) |
|
VAng-Lsx02232-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Escherichia coli Colicin-Ib immunity protein, recombinant protein. |
 IgG) Goat Anti-Human recombinant Fetuin A (Alpha-2 HS-Glycoprotein, AHSG, A2HS) IgG |
|
FETB12-A |
Alpha Diagnostics |
100 ug |
EUR 482 |
 peptid IgG, aff pure) Goat Anti-Human Apolipoprotein A-IV A(ApoA4) peptid IgG, aff pure |
|
APOA45-A |
Alpha Diagnostics |
100 ul |
EUR 482 |
 IgG) Rabbit Anti-human MART-1/Melanocyte Differentiation-A/Melan-A peptide (CT) IgG |
|
MART12-A |
Alpha Diagnostics |
100 ul |
EUR 445 |
 (a. a. 155)) Recombinant Human Fibroblast Growth Factor 2 (Basic) (a. a. 155) |
|
DAG302 |
Creative Diagnostics |
50ug |
EUR 748 |
 PDGF-A Platelet-Derived Growth Factor A Human Recombinant Protein |
|
PROTP04085-2 |
BosterBio |
Regular: 20ug |
EUR 317 |
|
Description: Platelet-Derived Growth Factor A Human Recombinant short chain produced in E.Coli is a non-glycosylated, polypeptide chain containing 110 amino acids fragment (87-196) and having a total Mw of 17.02kDa, with an amino-terminal hexahistidine tag. ;PDGF-A is purified by proprietary chromatographic techniques. |
 HGF-A Hepatocyte Growth Factor A Chain Human Recombinant Protein |
|
PROTP14210-4 |
BosterBio |
Regular: 10ug |
EUR 317 |
|
Description: HGF-A Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 463 amino acids fragment (32-494) having a total molecular weight of 57.8kDa. The HGF-A is fused with a 4.5kDa amino-terminal hexahistidine tag.;The HGF-A is purified by proprietary chromatographic techniques. |
 Mating Factor a |
|
H-7724.0001 |
Bachem |
1.0mg |
EUR 96 |
|
Description: Sum Formula: C82H114N20O17S; CAS# [59401-28-4] net |
Mating Factor a |
|
H-2925.0001 |
Bachem |
1.0mg |
EUR 126 |
|
Description: Sum Formula: C82H114N20O17S; CAS# [59401-28-4] net |
Mating Factor a |
|
H-2925.0005 |
Bachem |
5.0mg |
EUR 418 |
|
Description: Sum Formula: C82H114N20O17S; CAS# [59401-28-4] net |
 Boc-a-Me-DL-Val-OH |
|
A-4145.0001 |
Bachem |
1.0g |
EUR 139 |
|
Description: Sum Formula: C11H21NO4; CAS# [139938-00-4] |
Boc-a-Me-DL-Val-OH |
|
A-4145.0005 |
Bachem |
5.0g |
EUR 477 |
|
Description: Sum Formula: C11H21NO4; CAS# [139938-00-4] |
 Recombinant Human Platelet Derived Growth Factor-A |
|
7-01351 |
CHI Scientific |
5µg |
Ask for price |
Recombinant Human Platelet Derived Growth Factor-A |
|
7-01352 |
CHI Scientific |
20µg |
Ask for price |
Recombinant Human Platelet Derived Growth Factor-A |
|
7-01353 |
CHI Scientific |
1mg |
Ask for price |
 Recombinant Human Hepatocyte Growth Factor A Chain |
|
7-00631 |
CHI Scientific |
2µg |
Ask for price |
Recombinant Human Hepatocyte Growth Factor A Chain |
|
7-00632 |
CHI Scientific |
10µg |
Ask for price |
Recombinant Human Hepatocyte Growth Factor A Chain |
|
7-00633 |
CHI Scientific |
1mg |
Ask for price |
Recombinant Human Platelet Derived Growth Factor-A |
|
CG093-005 |
GenDepot |
5ug |
EUR 293 |
Recombinant Human Platelet Derived Growth Factor-A |
|
CG093-020 |
GenDepot |
20ug |
EUR 408 |
Recombinant Human Platelet Derived Growth Factor-A |
|
CG093-101 |
GenDepot |
1mg |
EUR 7475 |
) Recombinant Nuclear Prelamin A Recognition Factor (NARF) |
|
4-RPC651Hu01 |
Cloud-Clone |
-
EUR 413.60
-
EUR 214.00
-
EUR 1276.00
-
EUR 492.00
-
EUR 884.00
-
EUR 340.00
-
EUR 3040.00
|
-
100 ug
-
10ug
-
1 mg
-
200 ug
-
500 ug
-
50ug
-
5 mg
|
- Uniprot ID: Q9UHQ1
- Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
- Form: Freeze-dried powder
- Predicted Molecular Mass (KD): 18.0kDa
- Isoelectric Point: 9.3
|
|
Description: Recombinant Human Nuclear Prelamin A Recognition Factor expressed in: E.coli |
) Recombinant Vascular Endothelial Growth Factor A (VEGFA) |
|
4-RPA143Bo01 |
Cloud-Clone |
-
EUR 565.92
-
EUR 254.00
-
EUR 1847.20
-
EUR 682.40
-
EUR 1264.80
-
EUR 442.00
-
EUR 4468.00
|
-
100 ug
-
10ug
-
1 mg
-
200 ug
-
500 ug
-
50ug
-
5 mg
|
- Uniprot ID: P15691
- Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
- Form: Freeze-dried powder
- Predicted Molecular Mass (KD): 17.8kDa
- Isoelectric Point: 7.6
|
|
Description: Recombinant Bovine Vascular Endothelial Growth Factor A expressed in: E.coli |
Recombinant Vascular Endothelial Growth Factor A (VEGFA) |
|
4-RPA143Ca01 |
Cloud-Clone |
-
EUR 637.60
-
EUR 274.00
-
EUR 2116.00
-
EUR 772.00
-
EUR 1444.00
-
EUR 490.00
-
EUR 5140.00
|
-
100 ug
-
10ug
-
1 mg
-
200 ug
-
500 ug
-
50ug
-
5 mg
|
- Uniprot ID: Q9MYV3
- Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
- Form: Freeze-dried powder
- Predicted Molecular Mass (KD): 19.1kDa
- Isoelectric Point: Inquire
|
|
Description: Recombinant Dog Vascular Endothelial Growth Factor A expressed in: E.coli |
Recombinant Vascular Endothelial Growth Factor A (VEGFA) |
|
4-RPA143Hu01 |
Cloud-Clone |
-
EUR 476.32
-
EUR 230.00
-
EUR 1511.20
-
EUR 570.40
-
EUR 1040.80
-
EUR 382.00
-
EUR 3628.00
|
-
100 ug
-
10ug
-
1 mg
-
200 ug
-
500 ug
-
50ug
-
5 mg
|
- Uniprot ID: P15692
- Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
- Form: Freeze-dried powder
- Predicted Molecular Mass (KD): 20.6kDa
- Isoelectric Point: 6.9
|
|
Description: Recombinant Human Vascular Endothelial Growth Factor A expressed in: E.coli |
Recombinant Vascular Endothelial Growth Factor A (VEGFA) |
|
4-RPA143Mu01 |
Cloud-Clone |
-
EUR 530.08
-
EUR 245.00
-
EUR 1712.80
-
EUR 637.60
-
EUR 1175.20
-
EUR 418.00
-
EUR 4132.00
|
-
100 ug
-
10ug
-
1 mg
-
200 ug
-
500 ug
-
50ug
-
5 mg
|
- Uniprot ID: Q00731
- Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
- Form: Freeze-dried powder
- Predicted Molecular Mass (KD): 17.8kDa
- Isoelectric Point: 6.5
|
|
Description: Recombinant Mouse Vascular Endothelial Growth Factor A expressed in: E.coli |
Recombinant Vascular Endothelial Growth Factor A (VEGFA) |
|
4-RPA143Po01 |
Cloud-Clone |
-
EUR 530.08
-
EUR 245.00
-
EUR 1712.80
-
EUR 637.60
-
EUR 1175.20
-
EUR 418.00
-
EUR 4132.00
|
-
100 ug
-
10ug
-
1 mg
-
200 ug
-
500 ug
-
50ug
-
5 mg
|
- Uniprot ID: P49151
- Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
- Form: Freeze-dried powder
- Predicted Molecular Mass (KD): 51.2kDa
- Isoelectric Point: 6.5
|
|
Description: Recombinant Pig Vascular Endothelial Growth Factor A expressed in: E.coli |
Recombinant Vascular Endothelial Growth Factor A (VEGFA) |
|
4-RPA143Ra01 |
Cloud-Clone |
-
EUR 530.08
-
EUR 245.00
-
EUR 1712.80
-
EUR 637.60
-
EUR 1175.20
-
EUR 418.00
-
EUR 4132.00
|
-
100 ug
-
10ug
-
1 mg
-
200 ug
-
500 ug
-
50ug
-
5 mg
|
- Uniprot ID: P16612
- Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
- Form: Freeze-dried powder
- Predicted Molecular Mass (KD): 20.8kDa
- Isoelectric Point: 7.5
|
|
Description: Recombinant Rat Vascular Endothelial Growth Factor A expressed in: E.coli |
Recombinant Vascular Endothelial Growth Factor A (VEGFA) |
|
4-RPA143Rb01 |
Cloud-Clone |
-
EUR 530.08
-
EUR 245.00
-
EUR 1712.80
-
EUR 637.60
-
EUR 1175.20
-
EUR 418.00
-
EUR 4132.00
|
-
100 ug
-
10ug
-
1 mg
-
200 ug
-
500 ug
-
50ug
-
5 mg
|
- Uniprot ID: Q866G4
- Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
- Form: Freeze-dried powder
- Predicted Molecular Mass (KD): 17.9kDa
- Isoelectric Point: 6.2
|
|
Description: Recombinant Rabbit Vascular Endothelial Growth Factor A expressed in: E.coli |
Recombinant Vascular Endothelial Growth Factor A (VEGFA) |
|
4-RPA143Si01 |
Cloud-Clone |
-
EUR 574.88
-
EUR 257.00
-
EUR 1880.80
-
EUR 693.60
-
EUR 1287.20
-
EUR 448.00
-
EUR 4552.00
|
-
100 ug
-
10ug
-
1 mg
-
200 ug
-
500 ug
-
50ug
-
5 mg
|
- Uniprot ID: Inquire
- Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
- Form: Freeze-dried powder
- Predicted Molecular Mass (KD): 25.1kDa
- Isoelectric Point: 9.2
|
|
Description: Recombinant Simian Vascular Endothelial Growth Factor A expressed in: E.coli |
 TFAM Transcription Factor-A Recombinant Protein Human |
|
PROTQ00059 |
BosterBio |
Regular: 5ug |
EUR 317 |
|
Description: TFAM produced in E.Coli is a single, non-glycosylated polypeptide chain containing 225 amino acids (43-246.a.a) and having a molecular mass of 26.6kDa. ;TFAM is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
 (A/Wyoming/3/03) protein IgG, aff pure) Rabbit Anti-Influenza A HA (H1N1, 1-343aa) (A/Wyoming/3/03) protein IgG, aff pure |
|
H3N22-A |
Alpha Diagnostics |
100 ul |
EUR 445 |
-OH) Fmoc-a-amino-DL-Gly(Boc)-OH |
|
A-4320.0001 |
Bachem |
1.0g |
EUR 273 |
|
Description: Sum Formula: C22H24N2O6; CAS# [176039-39-7] |
Fmoc-a-amino-DL-Gly(Boc)-OH |
|
A-4320.0005 |
Bachem |
5.0g |
EUR 998 |
|
Description: Sum Formula: C22H24N2O6; CAS# [176039-39-7] |
 protein (A/06/California/2009) IgG, aff pure) Rabbit Anti-Influenza A nucleoprotein (H1N1-NP/1-320aa) protein (A/06/California/2009) IgG, aff pure |
|
H1NP21-A |
Alpha Diagnostics |
100 ul |
EUR 445 |
 (A/Vietnam/1203/2004 366-531aa, >95%, his-tag) protein IgG) Rabbit Anti-Influenza A HA2 (H5N1) (A/Vietnam/1203/2004 366-531aa, >95%, his-tag) protein IgG |
|
HA2H012-A |
Alpha Diagnostics |
100 ul |
EUR 445 |
 Polypeptide) Recombinant Human Insulin Like Growth Factor I (a. a. 70) Polypeptide |
|
DAG296 |
Creative Diagnostics |
100ug |
EUR 879 |
 (A/Brisbane/10/2007) protein IgG, aff pure) Rabbit Anti-Influenza A HA (H3N2, 1-531aa/HA1+HA2) (A/Brisbane/10/2007) protein IgG, aff pure |
|
H3N23-A |
Alpha Diagnostics |
100 ul |
EUR 445 |
 IgG) Goat Anti-Hepatitis A Virus (Strain HM175) IgG |
|
HAV11-A |
Alpha Diagnostics |
100 ul |
EUR 457 |
 antiserum) Goat Anti-human Serum Amyloid A (SAA) antiserum |
|
SAA11-A |
Alpha Diagnostics |
100 ul |
EUR 482 |
 Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-100ug |
|
QP6236-ec-100ug |
EnQuireBio |
100ug |
EUR 408 |
 Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-10ug |
|
QP6236-ec-10ug |
EnQuireBio |
10ug |
EUR 200 |
 Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-1mg |
|
QP6236-ec-1mg |
EnQuireBio |
1mg |
EUR 1632 |
 Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-200ug |
|
QP6236-ec-200ug |
EnQuireBio |
200ug |
EUR 634 |
 Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-500ug |
|
QP6236-ec-500ug |
EnQuireBio |
500ug |
EUR 1060 |
 Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-50ug |
|
QP6236-ec-50ug |
EnQuireBio |
50ug |
EUR 263 |
) Recombinant Escherichia coli Colicin-E5 immunity protein in ColE9 (aa 1-83) |
|
VAng-Lsx02228-1mgEcoli |
Creative Biolabs |
1 mg (E. coli) |
EUR 2759 |
|
Description: Escherichia coli Colicin-E5 immunity protein in ColE9, recombinant protein. |
Recombinant Escherichia coli Colicin-E5 immunity protein in ColE9 (aa 1-83) |
|
VAng-Lsx02228-500gEcoli |
Creative Biolabs |
500 µg (E. coli) |
EUR 1961 |
|
Description: Escherichia coli Colicin-E5 immunity protein in ColE9, recombinant protein. |
Recombinant Escherichia coli Colicin-E5 immunity protein in ColE9 (aa 1-83) |
|
VAng-Lsx02228-50gEcoli |
Creative Biolabs |
50 µg (E. coli) |
EUR 1356 |
|
Description: Escherichia coli Colicin-E5 immunity protein in ColE9, recombinant protein. |
 Recombinant human Transcription elongation factor A protein 3 |
|
P2240 |
FN Test |
100ug |
Ask for price |
- Uniprot ID: O75764
- Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
|
|
Description: Recombinant protein for human Transcription elongation factor A protein 3 |
 Recombinant human Chromatin assembly factor 1 subunit A |
|
P2784 |
FN Test |
100ug |
Ask for price |
- Uniprot ID: Q13111
- Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
|
|
Description: Recombinant protein for human Chromatin assembly factor 1 subunit A |
) Recombinant Platelet Derived Growth Factor Subunit A (PDGFA) |
|
4-RPA528Ra01 |
Cloud-Clone |
-
EUR 404.64
-
EUR 211.00
-
EUR 1242.40
-
EUR 480.80
-
EUR 861.60
-
EUR 334.00
-
EUR 2956.00
|
-
100 ug
-
10ug
-
1 mg
-
200 ug
-
500 ug
-
50ug
-
5 mg
|
- Uniprot ID: Inquire
- Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
- Form: Freeze-dried powder
- Predicted Molecular Mass (KD): 15.2kDa
- Isoelectric Point: 9.1
|
|
Description: Recombinant Rat Platelet Derived Growth Factor Subunit A expressed in: E.coli |
 Antibody) Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
20-abx126951 |
Abbexa |
|
|
- Shipped within 5-10 working days.
|
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
abx026104-400ul |
Abbexa |
400 ul |
EUR 523 |
- Shipped within 5-10 working days.
|
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
abx026104-80l |
Abbexa |
80 µl |
EUR 286 |
- Shipped within 5-10 working days.
|
 Antibody) Immunity-Related GTPase Family Q Protein (IRGQ) Antibody |
|
abx032348-400ul |
Abbexa |
400 ul |
EUR 551 |
- Shipped within 5-10 working days.
|
Immunity-Related GTPase Family Q Protein (IRGQ) Antibody |
|
abx032348-80l |
Abbexa |
80 µl |
EUR 321 |
- Shipped within 5-10 working days.
|
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
20-abx321743 |
Abbexa |
|
|
- Shipped within 5-10 working days.
|
 Protein) Immunity-Related GTPase Family M Protein (IRGM) Protein |
|
20-abx260986 |
Abbexa |
-
EUR 3418.00
-
EUR 328.00
-
EUR 230.00
|
|
- Shipped within 5-10 working days.
|
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
20-abx339551 |
Abbexa |
|
|
- Shipped within 5-10 working days.
|
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
abx448534-100ug |
Abbexa |
100 ug |
EUR 523 |
- Shipped within 5-12 working days.
|
Immunity-Related GTPase Family Q Protein (IRGQ) Antibody |
|
abx234399-100ug |
Abbexa |
100 ug |
EUR 551 |
- Shipped within 5-12 working days.
|
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
20-abx210849 |
Abbexa |
|
|
- Shipped within 5-10 working days.
|
) Human Immunity-related GTPase family M protein (IRGM) |
|
1-CSB-EP011827HU |
Cusabio |
-
EUR 380.00
-
EUR 214.00
-
EUR 1309.00
-
EUR 560.00
-
EUR 873.00
-
EUR 262.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 47.1 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Human Immunity-related GTPase family M protein(IRGM) expressed in E.coli |
 Rabbit Anti-Human Calcineurin A-subunit IgG aff pure |
|
CALNA12-A |
Alpha Diagnostics |
100 ug |
EUR 482 |
 Fmoc-Mating Factor a |
|
B-1620.0001 |
Bachem |
1.0mg |
EUR 126 |
|
Description: Sum Formula: C97H124N20O19S; CAS# [250642-63-8] |
Fmoc-Mating Factor a |
|
B-1620.0005 |
Bachem |
5.0mg |
EUR 418 |
|
Description: Sum Formula: C97H124N20O19S; CAS# [250642-63-8] |
 Factor XIII A Antibody |
|
20-abx009275 |
Abbexa |
-
EUR 300.00
-
EUR 439.00
-
EUR 189.00
|
|
- Shipped within 5-10 working days.
|
, Polypeptide) Recombinant Human Colony Stimulating Factor 1 (a. a. 2 x 159), Polypeptide |
|
DAG292 |
Creative Diagnostics |
25ug |
EUR 971 |
 Rabbit Anti-Human Apolipoprotein A-I protein IgG, aff pure |
|
APOA12-A |
Alpha Diagnostics |
100 ug |
EUR 482 |
 Rabbit Anti-Mouse Apolipoprotein A-I protein IgG, aff pure |
|
APOA13-A |
Alpha Diagnostics |
100 ug |
EUR 482 |
 Goat Anti-Human Apolipoprotein A-Il protein IgG, aff pure |
|
APOA21-A |
Alpha Diagnostics |
100 ug |
EUR 482 |
 protein, IgG) Goat Anti-Green Fluorescent Proteins (GFP, A. victoria) protein, IgG |
|
GFP11-A |
Alpha Diagnostics |
100 ul |
EUR 408 |
 Rabbit Anti-Mouse a-1-Acid Glycoprotein IgG, aff pure |
|
A1AG18-A |
Alpha Diagnostics |
100 ug |
EUR 482 |
 Rabbit Anti-Rat a-1-Acid Glycoprotein IgG, aff pure |
|
A1AG19-A |
Alpha Diagnostics |
100 ug |
EUR 482 |
 Rabbit Anti-Mouse prepro Orexin A IgG # 1, aff pure |
|
PPOX11-A |
Alpha Diagnostics |
100 ul |
EUR 482 |
 Rabbit Anti-Rat/Human Orexin-A IgG # 1, aff pure |
|
OXA11-A |
Alpha Diagnostics |
100 ug |
EUR 482 |
 protein (A/Viet Nam/1203/2004(H5N1) IgG, aff pure) Rabbit Anti-Influenza A hemeagglutinin A2 (HA2/stem or stalk domain/347-523aa) protein (A/Viet Nam/1203/2004(H5N1) IgG, aff pure |
|
HA28-A |
Alpha Diagnostics |
100 ul |
EUR 445 |
 IgG) Rabbit Anti-Hemagglutinin HA1 Influenza A Virus (H11N2; A/duck/Yangzhou/906/2002) IgG |
|
H11N2-01-A |
Alpha Diagnostics |
100 ul |
EUR 482 |
 protein, IgG, aff pure) Rabbit Anti-bovine Calcineurin (A+B subunits) protein, IgG, aff pure |
|
CALN11-A |
Alpha Diagnostics |
100 ug |
EUR 482 |
 IgG, aff pure) Rabbit Anti-Borrelia burgdorferi Osp-A protein (OspA) IgG, aff pure |
|
OSPA12-A |
Alpha Diagnostics |
100 ul |
EUR 482 |
 IgG) Goat Anti-Anthrax Edema Factor (B Anthracis) IgG |
|
EF11-A |
Alpha Diagnostics |
100 ug |
EUR 408 |
 IgG, Purified) Sheep Anti-Human Prothrombin (Factor II) IgG, Purified |
|
PRTN11-A |
Alpha Diagnostics |
1 mg |
EUR 225 |
 IgG, Purified) Sheep Anti-Mouse Prothrombin (Factor II) IgG, Purified |
|
PRTN13-A |
Alpha Diagnostics |
100ul |
EUR 482 |
) Recombinant Human Coagulation Factor XIII A Chain (C-6His) |
|
C880-10ug |
Novoprotein |
10ug |
EUR 156 |
|
Description: Supplied as a 0.2 μm filtered solution of 50 mM NaCl,5% Sucrose, 1% Tween 20 (v/v),0.3% Histidine (w/v),pH8.0. |
Recombinant Human Coagulation Factor XIII A Chain (C-6His) |
|
C880-1mg |
Novoprotein |
1mg |
EUR 1877 |
|
Description: Supplied as a 0.2 μm filtered solution of 50 mM NaCl,5% Sucrose, 1% Tween 20 (v/v),0.3% Histidine (w/v),pH8.0. |
Recombinant Human Coagulation Factor XIII A Chain (C-6His) |
|
C880-500ug |
Novoprotein |
500ug |
EUR 1328 |
|
Description: Supplied as a 0.2 μm filtered solution of 50 mM NaCl,5% Sucrose, 1% Tween 20 (v/v),0.3% Histidine (w/v),pH8.0. |
Recombinant Human Coagulation Factor XIII A Chain (C-6His) |
|
C880-50ug |
Novoprotein |
50ug |
EUR 369 |
|
Description: Supplied as a 0.2 μm filtered solution of 50 mM NaCl,5% Sucrose, 1% Tween 20 (v/v),0.3% Histidine (w/v),pH8.0. |
-Like 1) Recombinant Human Transcription Elongation Factor A (SII)-Like 1 |
|
7-06619 |
CHI Scientific |
5µg |
Ask for price |
Recombinant Human Transcription Elongation Factor A (SII)-Like 1 |
|
7-06620 |
CHI Scientific |
20µg |
Ask for price |
Recombinant Human Transcription Elongation Factor A (SII)-Like 1 |
|
7-06621 |
CHI Scientific |
1mg |
Ask for price |
 TNF-a Tumor Necrosis Factor-Alpha Rabbit Recombinant Protein |
|
PROTP04924 |
BosterBio |
Regular: 20ug |
EUR 317 |
|
Description: Tumor Necrosis Factor-a Rabbit Recombinant consists of three identical polypeptide chains of 158 amino acids combined to form a compact, bell-shaped homotrimer. TNF-alpha was produced in E.Coli is a non-glycosylated, polypeptide chain having a molecular mass of 17.4 kDa for the individual subunit. ;The TNF-alpha is purified by standard chromatographic techniques. |
 TNF-a Tumor Necrosis Factor-Alpha Mouse Recombinant Protein |
|
PROTP06804 |
BosterBio |
Regular: 20ug |
EUR 317 |
|
Description: Tumor Necrosis Factor-a Mouse Recombinant produced in E. coli is a single, non glycosylated, polypeptide chain containing 157 amino acids and having a molecular mass of 17301.32 Dalton. ;The TNF-alpha is purified by standard chromatographic techniques. |
 TNF-a Tumor Necrosis Factor-Alpha Rat Recombinant Protein |
|
PROTP16599 |
BosterBio |
Regular: 20ug |
EUR 317 |
|
Description: Tumor Necrosis Factor-a Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 157 amino acids and having a molecular mass of 17339.44 Dalton. The TNF-alpha is purified by standard chromatographic techniques. |
 TNF-a Tumor Necrosis Factor-Alpha Porcine Recombinant Protein |
|
PROTP23563 |
BosterBio |
Regular: 20ug |
EUR 317 |
|
Description: Tumor Necrosis Factor-a Porcine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 157 amino acids and having a molecular mass of 17,274 Dalton. The TNF-alpha is purified by standard chromatographic techniques. |
 Recombinant human Pre-mRNA-processing factor 40 homolog A |
|
P2804 |
FN Test |
100ug |
Ask for price |
- Uniprot ID: O75400
- Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
|
|
Description: Recombinant protein for human Pre-mRNA-processing factor 40 homolog A |
 TNF-a Tumor Necrosis Factor-Alpha Canine Recombinant Protein |
|
PROTP51742 |
BosterBio |
Regular: 20ug |
EUR 317 |
|
Description: TNF-a Canine Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 157 amino acids and having a molecular mass of 17.3 kDa. ;The TNF-a is purified by proprietary chromatographic techniques. |
 Antibody (ALP)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (ALP) |
|
abx448005-100ug |
Abbexa |
100 ug |
EUR 578 |
- Shipped within 5-12 working days.
|
 Antibody (APC)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (APC) |
|
abx448006-100ug |
Abbexa |
100 ug |
EUR 578 |
- Shipped within 5-12 working days.
|
 Antibody (Biotin)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (Biotin) |
|
abx448007-100ug |
Abbexa |
100 ug |
EUR 578 |
- Shipped within 5-12 working days.
|
 Antibody (FITC)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (FITC) |
|
abx448008-100ug |
Abbexa |
100 ug |
EUR 565 |
- Shipped within 5-12 working days.
|
 Antibody (HRP)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (HRP) |
|
abx448009-100ug |
Abbexa |
100 ug |
EUR 565 |
- Shipped within 5-12 working days.
|
 Antibody (PerCP)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (PerCP) |
|
abx448011-100ug |
Abbexa |
100 ug |
EUR 578 |
- Shipped within 5-12 working days.
|
 Antibody (RPE)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (RPE) |
|
abx448012-100ug |
Abbexa |
100 ug |
EUR 578 |
- Shipped within 5-12 working days.
|
 Antibody (Streptavidin)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (Streptavidin) |
|
abx448013-100ug |
Abbexa |
100 ug |
EUR 578 |
- Shipped within 5-12 working days.
|
 (A/New Caledonia/20/99) IgG) Rabbit Anti-Hemagglutinin Influenza A Virus H1N1 H1 (H1N1) (A/New Caledonia/20/99) IgG |
|
H1N1-01-A |
Alpha Diagnostics |
100 ul |
EUR 482 |
 Goat Anti-Human/mouse/rat Insulin chain A peptide IgG, aff pure |
|
INSA21-A |
Alpha Diagnostics |
100 ul |
EUR 482 |
 IgG #1, aff. pure) Rabbit Anti-Rat neurite outgrowth inhibitor (Nogo-A) IgG #1, aff. pure |
|
NogoA11-A |
Alpha Diagnostics |
100 ug |
EUR 482 |
 Antibody) Vascular Endothelial Growth Factor A-A (vegfaa) Antibody |
|
20-abx320017 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
 IgG #1, Aff. Pure) Rabbit Anti-Rat Epithelial Na Channel alpha (ENAC-a) IgG #1, Aff. Pure |
|
ENACa11-A |
Alpha Diagnostics |
100 ug |
EUR 482 |
While numerous advances have been made to mitigate this difficulty, together with the usage of chemical substances, excisable and non-integrating vectors, and use of the modified mRNA, security stays a priority. Both integrating and non-integrating strategies additionally endure from many different limitations together with low effectivity, variability, and tumorigenicity.
The non-integrating mRNA reprogramming is of excessive effectivity, however it’s delicate to reagents and want approaches to cut back the immunogenic response. An various non-integrating and safer approach of producing iPSCs is through direct supply of recombinant cell-penetrating reprogramming proteins into the cells to be reprogrammed, however reprogramming effectivity of the protein-based strategy is extraordinarily low in comparison with the traditional virus-based nuclear reprogramming. Herein, we describe detailed steps for environment friendly era of human iPSCs by protein-based reprogramming in mixture with stimulation of the Toll-like receptor 3 (TLR3) innate immune pathway.
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 vaccine Identification ELISA Kit, 24 tests)
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