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Induction of Cross-reactive Hemagglutination Inhibiting Antibody and Polyfunctional CD4+ T-cell Responses by a Recombinant Matrix-M-Adjuvanted Hemagglutinin Nanoparticle Influenza Vaccine

by
Identification and characterization of CD4+ T cell epitopes after Shingrix vaccination
Recurrent experiences of suboptimal influenza vaccine effectiveness have renewed calls to develop improved, broadly cross-protective influenza vaccines. Here, we evaluated the protection and immunogenicity of a novel, saponin (Matrix-M)-adjuvanted, recombinant hemagglutinin (HA) quadrivalent nanoparticle influenza vaccine (qNIV). We carried out a randomized, observer-blind, comparator-controlled (trivalent high-dose inactivated influenza vaccine [IIV3-HD]
or quadrivalent recombinant influenza vaccine [RIV4]), security and immunogenicity trial of qNIV (in 5 completely different doses/formulations) in wholesome adults aged ≥65 years. Vaccine immunogenicity was measured by hemagglutination-inhibition assays utilizing reagents expressing wild-type HA sequences (wt-HAI) and cell-mediated immune (CMI) responses. Only lately, nonetheless, have NHP MAIT cells been completely characterised utilizing macaque-specific MR1 tetramer reagents. Here we overview the similarities and variations between MAIT cells in people and NHPs in addition to the influence of SIV/SHIV an infection on MAIT cells and the potential implications for future analysis.
A complete of 1375 contributors had been randomized, immunized, and adopted for security and immunogenicity. Matrix-M-adjuvanted qNIV induced superior wt-HAI antibody responses towards 5 of 6 homologous or drifted strains evaluated in comparison with unadjuvanted qNIV. Adjuvanted qNIV induced post-vaccination wt-HAI antibody responses at Day 28 that had been: statistically greater than IIV3-HD towards a panel of homologous or drifted A/H3N2 strains; just like IIV3-HD towards homologous A/H1N1 and B (Victoria) strains; and just like RIV4 towards all homologous and drifted strains evaluated. The qNIV formulation with 75 µg Matrix-M adjuvant induced considerably greater post-vaccination geometric imply fold-increases of influenza HA-specific polyfunctional CD4+ T-cells in comparison with IIV3-HD or RIV4. Overall, related frequencies of solicited and unsolicited hostile occasions (AEs) had been reported in all therapy group

The N-terminal cysteine protease area of rice stripe tenuivirus Pc1 possesses deubiquitinating enzyme exercise

Virus encoded deubiquitinating enzyme (DUB) performs necessary roles in viral replication and the regulation of host innate immunity. Bioinformatics-based evaluation revealed the presence of an ovarian tumor (OTU) protease area within the N terminus of rice stripe tenuivirus (RSV) Pc1. Many viral OTU domains have been reported to own DUB exercise, which means that RSV OTU in all probability even have DUB exercise. To affirm this prediction, we first expressed and purified RSV OTU area (the N-terminal 200 amino acids of Pc1) and its three mutants (D42A, C45A and H148A) from Escherichia coli and analyzed its DUB exercise in vitro.

 

The purified RSV OTU hydrolyzed each Ok48-linked and Ok63-linked polyubiquitin chains, indicating RSV OTU area has DUB enzyme exercise in vitro. The mutations of the expected catalytic websites (Asp42, Cys45 and His148) resulted within the loss of DUB exercise, demonstrating these three residues had been required for enzyme exercise. Then, RSV OTU and its mutants had been expressed in insect cells and assayed their DUB actions in vivo by co-transfection with HA-tagged ubiquitin. RSV OTU dramatically lowered ubiquitin-conjugated mobile proteins in comparison with management and the mutants, exhibiting that RSV OTU additionally shows DUB exercise in vivo.

Characterization of RSV OTU DUB enzyme exercise and its key catalytic residues will facilitate the event of novel antiviral reagents towards RSV.Chronic HIV an infection causes systemic immune activation and dysregulation, ensuing within the impairment of most T-cell subsets together with MAIT cells. Multiple human cohort research display MAIT cells are selectively depleted within the peripheral blood and lymphoid tissues throughout HIV an infection, with incomplete restoration throughout suppressive antiretroviral remedy.

Because MAIT cells play an necessary function in mucosal protection towards a big range of pathogens, absolutely reconstituting the MAIT cell compartment in ART-treated populations may enhance immunity towards co-infections. Non-human primates (NHPs) are a useful, well-described animal mannequin for HIV an infection in people. NHPs additionally preserve MAIT cell frequencies extra corresponding to people, in comparison with different frequent animal fashions, and present a distinctive alternative to check MAIT cells within the circulation and mucosal tissues in a longitudinal method.

Induction of Cross-reactive Hemagglutination Inhibiting Antibody and Polyfunctional CD4+ T-cell Responses by a Recombinant Matrix-M-Adjuvanted Hemagglutinin Nanoparticle Influenza Vaccine

Serum Health Biomarkers in African and Asian Elephants: Value Ranges and Clinical Values Indicative of the Immune Response

Serum biomarkers indicative of irritation and illness can present helpful data concerning host immune processes, responses to therapy and prognosis. The goals of this research had been to evaluate the use of commercially accessible anti-equine reagents for the quantification of cytokines (tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), interleukins (IL) 2, 6, and 10) in African (Loxodonta africana, n = 125) and Asian (Elephas maximus, n = 104) elephants, and alongside beforehand validated anti-human reagents for acute-phase proteins (serum amyloid A and haptoglobin), calculate species-specific biomarker worth ranges. In addition, we used opportunistically collected samples to analyze the concentrations of every biomarker throughout recognized scientific circumstances of sickness or damage, as a first step to understanding what biomarkers could also be helpful to managing elephant well being.

Immunity-Related GTPase Family M Protein (IRGM) Antibody
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Immunity-Related GTPase Family M Protein (IRGM) Antibody
20-abx126951
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Immunity-Related GTPase Family Q Protein (IRGQ) Antibody
abx032348-400ul 400 ul
EUR 551
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Immunity-Related GTPase Family Q Protein (IRGQ) Antibody
abx032348-80l 80 µl
EUR 321
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Immunity-Related GTPase Family M Protein (IRGM) Protein
20-abx260986
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
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Immunity-Related GTPase Family M Protein (IRGM) Antibody
20-abx339551
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Immunity-Related GTPase Family Q Protein (IRGQ) Antibody
abx234399-100ug 100 ug
EUR 551
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Immunity-Related GTPase Family M Protein (IRGM) Antibody
20-abx321743
  • EUR 300.00
  • EUR 244.00
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Immunity-Related GTPase Family M Protein (IRGM) Antibody
abx448534-100ug 100 ug
EUR 523
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Immunity-Related GTPase Family M Protein (IRGM) Antibody (ALP)
abx448005-100ug 100 ug
EUR 578
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Immunity-Related GTPase Family M Protein (IRGM) Antibody (APC)
abx448006-100ug 100 ug
EUR 578
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Immunity-Related GTPase Family M Protein (IRGM) Antibody (Biotin)
abx448007-100ug 100 ug
EUR 578
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Immunity-Related GTPase Family M Protein (IRGM) Antibody (FITC)
abx448008-100ug 100 ug
EUR 565
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Immunity-Related GTPase Family M Protein (IRGM) Antibody (HRP)
abx448009-100ug 100 ug
EUR 565
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Immunity-Related GTPase Family M Protein (IRGM) Antibody (PerCP)
abx448011-100ug 100 ug
EUR 578
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Immunity-Related GTPase Family M Protein (IRGM) Antibody (RPE)
abx448012-100ug 100 ug
EUR 578
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Immunity-Related GTPase Family M Protein (IRGM) Antibody (Streptavidin)
abx448013-100ug 100 ug
EUR 578
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IRGM Immunity-Related GTPase Family, M Human Recombinant Protein
PROTA1A4Y4 Regular: 20ug
EUR 317
Description: IRGM Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 180 amino acids (23-181) and having a molecular mass of 20.1 kDa. IRGM is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Immunity Related GTPase M (IRGM) Antibody
abx412110-01mg 0.1 mg
EUR 537
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Human Immunity- related GTPase family Q protein, IRGQ ELISA KIT
ELI-13087h 96 Tests
EUR 824

Rat Immunity- related GTPase family M protein, Irgm ELISA KIT
ELI-20422r 96 Tests
EUR 886

Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 390)
abx447997-100ug 100 ug
EUR 578
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Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 488)
abx447998-100ug 100 ug
EUR 578
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Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 565)
abx447999-100ug 100 ug
EUR 578
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Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 594)
abx448000-100ug 100 ug
EUR 578
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Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 633)
abx448001-100ug 100 ug
EUR 578
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Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 655)
abx448002-100ug 100 ug
EUR 578
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Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 680)
abx448003-100ug 100 ug
EUR 578
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Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 700)
abx448004-100ug 100 ug
EUR 578
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Human Immunity-Related GTPase Family Q Protein (IRGQ) ELISA Kit
abx388031-96tests 96 tests
EUR 911
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Human Immunity- related GTPase family M protein, IRGM ELISA KIT
ELI-48787h 96 Tests
EUR 824

Mouse Immunity- related GTPase family Q protein, Irgq ELISA KIT
ELI-48788m 96 Tests
EUR 865

Mouse Immunity- related GTPase family M protein 1, Irgm1 ELISA K
ELI-43703m 96 Tests
EUR 865

Immunity-Related GTPase Family M Protein (IRGM) Antibody (PE/ATTO 594)
abx448010-100ug 100 ug
EUR 592
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Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-100ug
QP6236-ec-100ug 100ug
EUR 408

Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-10ug
QP6236-ec-10ug 10ug
EUR 200

Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-1mg
QP6236-ec-1mg 1mg
EUR 1632

Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-200ug
QP6236-ec-200ug 200ug
EUR 634

Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-500ug
QP6236-ec-500ug 500ug
EUR 1060

Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-50ug
QP6236-ec-50ug 50ug
EUR 263

Recombinant Human Rho Family GTPase 1
7-06157 5µg Ask for price

Recombinant Human Rho Family GTPase 1
7-06158 20µg Ask for price

Recombinant Human Rho Family GTPase 1
7-06159 1mg Ask for price

Recombinant Human Rho Family GTPase 3
7-06160 5µg Ask for price

Recombinant Human Rho Family GTPase 3
7-06161 20µg Ask for price

Recombinant Human Rho Family GTPase 3
7-06162 1mg Ask for price

DIRAS Family GTPase 3 (DIRAS3) Antibody
20-abx006587
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
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Rho Family GTPase 2 (RND2) Antibody
20-abx218322
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  • EUR 342.00
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DIRAS Family GTPase 3 (DIRAS3) Antibody
20-abx112094
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  • EUR 398.00
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Rho Family Gtpase 2 (RND2) Antibody
20-abx115176
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Rho Family Gtpase 3 (RND3) Antibody
20-abx115177
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Rho Family GTPase 2 (RND2) Antibody
20-abx121211
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
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Rho Family GTPase 1 (RND1) Antibody
20-abx130669
  • EUR 411.00
  • EUR 133.00
  • EUR 1149.00
  • EUR 565.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
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Rho Family GTPase 1 (RND1) Antibody
abx145149-100ug 100 ug
EUR 391
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DIRAS Family GTPase 3 (DIRAS3) Antibody
abx032656-400ul 400 ul
EUR 523
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DIRAS Family GTPase 3 (DIRAS3) Antibody
abx032656-80l 80 µl
EUR 286
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GTPase, IMAP Family Member 6 Protein
20-abx261940
  • EUR 4490.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

DIRAS Family GTPase 3 (DIRAS3) Antibody
20-abx339162
  • EUR 411.00
  • EUR 300.00
  • 100 ul
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DIRAS Family GTPase 3 (DIRAS3) Antibody
20-abx320343
  • EUR 300.00
  • EUR 244.00
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Rho Family GTPase 2 (RND2) Antibody
abx237332-100ug 100 ug
EUR 509
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Rho Family GTPase 2 (RND2) Antibody
20-abx318052
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

DIRAS Family GTPase 3 (DIRAS3) Antibody
20-abx225145
  • EUR 370.00
  • EUR 606.00
  • EUR 314.00
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GTPase, IMAP Family Member 5 Protein
20-abx262699
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

Recombinant Rho Family GTPase 1 (RND1)
4-RPB788Hu01
  • EUR 377.76
  • EUR 204.00
  • EUR 1141.60
  • EUR 447.20
  • EUR 794.40
  • EUR 316.00
  • EUR 2704.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q92730
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 29.4kDa
  • Isoelectric Point: Inquire
Description: Recombinant Human Rho Family GTPase 1 expressed in: E.coli

GTPase IMAP Family Member 4 (GIMAP4) Antibody
20-abx008113
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
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GTPase IMAP Family Member 8 (GIMAP8) Antibody
abx027293-400ul 400 ul
EUR 523
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GTPase IMAP Family Member 8 (GIMAP8) Antibody
abx027293-80l 80 µl
EUR 286
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GTPase IMAP Family Member 7 (GIMAP7) Antibody
20-abx216118
  • EUR 425.00
  • EUR 342.00
  • 100 ug
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GTPase IMAP Family Member 2 (GIMAP2) Antibody
20-abx112878
  • EUR 732.00
  • EUR 398.00
  • 150 ul
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GTPase IMAP Family Member 4 (GIMAP4) Antibody
20-abx112879
  • EUR 732.00
  • EUR 398.00
  • 150 ul
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GTPase IMAP Family Member 5 (GIMAP5) Antibody
20-abx112880
  • EUR 732.00
  • EUR 398.00
  • 150 ul
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GTPase IMAP Family Member 7 (GIMAP7) Antibody
20-abx112881
  • EUR 732.00
  • EUR 398.00
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GTPase IMAP Family Member 5 (GIMAP5) Antibody
20-abx124690
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
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GTPase IMAP Family Member 4 (GIMAP4) Antibody
abx146087-100ug 100 ug
EUR 391
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Human Rho Family GTPase 1 (RND1) Protein
20-abx168764
  • EUR 537.00
  • EUR 244.00
  • EUR 1553.00
  • EUR 634.00
  • EUR 398.00
  • 100 ug
  • 10 ug
  • 1 mg
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  • Shipped within 5-7 working days.

GTPase IMAP Family Member 2 (GIMAP2) Antibody
20-abx014508
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 4 (GIMAP4) Antibody
20-abx014509
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 5 (GIMAP5) Antibody
20-abx014510
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

Human Rho family GTPase 1 ELISA Kit
ELA-E1788h 96 Tests
EUR 824

GTPase IMAP Family Member 2 (GIMAP2) Antibody
abx233456-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

GTPase IMAP Family Member 4 (GIMAP4) Antibody
abx233457-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

GTPase IMAP Family Member 5 (GIMAP5) Antibody
abx233458-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

GTPase IMAP Family Member 7 (GIMAP7) Antibody
abx233459-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Rho Family GTPase 2 (RND2) Antibody (HRP)
20-abx315972
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Rho Family GTPase 2 (RND2) Antibody (FITC)
20-abx315973
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Rho Family GTPase 2 (RND2) Antibody (Biotin)
20-abx315974
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 2 (GIMAP2) Antibody
abx330512-100ul 100 ul
EUR 425
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GTPase IMAP Family Member 5 (GIMAP5) Antibody
abx330629-100ul 100 ul
EUR 425
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GTPase IMAP Family Member 4 (GIMAP4) Antibody
abx330973-100ul 100 ul
EUR 425
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 2 (GIMAP2) Antibody
20-abx324240
  • EUR 314.00
  • EUR 244.00
  • 100 ug
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GTPase IMAP Family Member 5 (GIMAP5) Antibody
20-abx324499
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 4 (GIMAP4) Antibody
20-abx324751
  • EUR 314.00
  • EUR 244.00
  • 100 ug
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GTPase IMAP Family Member 7 (GIMAP7) Antibody
20-abx302667
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Recombinant human GTPase IMAP family member 1
P2329 100ug Ask for price
  • Uniprot ID: Q8WWP7
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for human GTPase IMAP family member 1

Human Tumor Immunity Primer Library
HTIMU-I 1 set
EUR 548

Mouse Tumor Immunity Primer Library
MTIMU-I 1 set
EUR 548

Secretion Associated Ras Related GTPase 1B (SAR1B) Antibody
abx025703-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Immune biomarkers had been every elevated above the calculated species-specific worth ranges in a minimum of one scientific case, however resulting from variability in each scientific and non-clinical samples, solely serum amyloid A was considerably greater in scientific in comparison with non-clinical paired samples, with tendencies for greater TNF-α and IL-10. We additionally detected elevated secretion of serum amyloid A and all 5 cytokines following routine vaccination of a single Asian elephant, indicating that these biomarkers will be helpful for finding out regular immune processes in addition to pathology. This research signifies that assays developed with industrial reagents can be utilized to quantify well being biomarkers in wildlife species and identifies a number of that warrant additional investigation to elucidate immune responses to varied pathologies.