Induction of Cross-reactive Hemagglutination Inhibiting Antibody and Polyfunctional CD4+ T-cell Responses by a Recombinant Matrix-M-Adjuvanted Hemagglutinin Nanoparticle Influenza Vaccine

Identification and characterization of CD4+ T cell epitopes after Shingrix vaccination
Recurrent experiences of suboptimal influenza vaccine effectiveness have renewed calls to develop improved, broadly cross-protective influenza vaccines. Here, we evaluated the protection and immunogenicity of a novel, saponin (Matrix-M)-adjuvanted, recombinant hemagglutinin (HA) quadrivalent nanoparticle influenza vaccine (qNIV). We carried out a randomized, observer-blind, comparator-controlled (trivalent high-dose inactivated influenza vaccine [IIV3-HD]
or quadrivalent recombinant influenza vaccine [RIV4]), security and immunogenicity trial of qNIV (in 5 completely different doses/formulations) in wholesome adults aged ≥65 years. Vaccine immunogenicity was measured by hemagglutination-inhibition assays utilizing reagents expressing wild-type HA sequences (wt-HAI) and cell-mediated immune (CMI) responses. Only lately, nonetheless, have NHP MAIT cells been completely characterised utilizing macaque-specific MR1 tetramer reagents. Here we overview the similarities and variations between MAIT cells in people and NHPs in addition to the influence of SIV/SHIV an infection on MAIT cells and the potential implications for future analysis.
A complete of 1375 contributors had been randomized, immunized, and adopted for security and immunogenicity. Matrix-M-adjuvanted qNIV induced superior wt-HAI antibody responses towards 5 of 6 homologous or drifted strains evaluated in comparison with unadjuvanted qNIV. Adjuvanted qNIV induced post-vaccination wt-HAI antibody responses at Day 28 that had been: statistically greater than IIV3-HD towards a panel of homologous or drifted A/H3N2 strains; just like IIV3-HD towards homologous A/H1N1 and B (Victoria) strains; and just like RIV4 towards all homologous and drifted strains evaluated. The qNIV formulation with 75 µg Matrix-M adjuvant induced considerably greater post-vaccination geometric imply fold-increases of influenza HA-specific polyfunctional CD4+ T-cells in comparison with IIV3-HD or RIV4. Overall, related frequencies of solicited and unsolicited hostile occasions (AEs) had been reported in all therapy group

The N-terminal cysteine protease area of rice stripe tenuivirus Pc1 possesses deubiquitinating enzyme exercise

Virus encoded deubiquitinating enzyme (DUB) performs necessary roles in viral replication and the regulation of host innate immunity. Bioinformatics-based evaluation revealed the presence of an ovarian tumor (OTU) protease area within the N terminus of rice stripe tenuivirus (RSV) Pc1. Many viral OTU domains have been reported to own DUB exercise, which means that RSV OTU in all probability even have DUB exercise. To affirm this prediction, we first expressed and purified RSV OTU area (the N-terminal 200 amino acids of Pc1) and its three mutants (D42A, C45A and H148A) from Escherichia coli and analyzed its DUB exercise in vitro.

 

The purified RSV OTU hydrolyzed each Ok48-linked and Ok63-linked polyubiquitin chains, indicating RSV OTU area has DUB enzyme exercise in vitro. The mutations of the expected catalytic websites (Asp42, Cys45 and His148) resulted within the loss of DUB exercise, demonstrating these three residues had been required for enzyme exercise. Then, RSV OTU and its mutants had been expressed in insect cells and assayed their DUB actions in vivo by co-transfection with HA-tagged ubiquitin. RSV OTU dramatically lowered ubiquitin-conjugated mobile proteins in comparison with management and the mutants, exhibiting that RSV OTU additionally shows DUB exercise in vivo.

Characterization of RSV OTU DUB enzyme exercise and its key catalytic residues will facilitate the event of novel antiviral reagents towards RSV.Chronic HIV an infection causes systemic immune activation and dysregulation, ensuing within the impairment of most T-cell subsets together with MAIT cells. Multiple human cohort research display MAIT cells are selectively depleted within the peripheral blood and lymphoid tissues throughout HIV an infection, with incomplete restoration throughout suppressive antiretroviral remedy.

Because MAIT cells play an necessary function in mucosal protection towards a big range of pathogens, absolutely reconstituting the MAIT cell compartment in ART-treated populations may enhance immunity towards co-infections. Non-human primates (NHPs) are a useful, well-described animal mannequin for HIV an infection in people. NHPs additionally preserve MAIT cell frequencies extra corresponding to people, in comparison with different frequent animal fashions, and present a distinctive alternative to check MAIT cells within the circulation and mucosal tissues in a longitudinal method.

Induction of Cross-reactive Hemagglutination Inhibiting Antibody and Polyfunctional CD4+ T-cell Responses by a Recombinant Matrix-M-Adjuvanted Hemagglutinin Nanoparticle Influenza Vaccine

Serum Health Biomarkers in African and Asian Elephants: Value Ranges and Clinical Values Indicative of the Immune Response

Serum biomarkers indicative of irritation and illness can present helpful data concerning host immune processes, responses to therapy and prognosis. The goals of this research had been to evaluate the use of commercially accessible anti-equine reagents for the quantification of cytokines (tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), interleukins (IL) 2, 6, and 10) in African (Loxodonta africana, n = 125) and Asian (Elephas maximus, n = 104) elephants, and alongside beforehand validated anti-human reagents for acute-phase proteins (serum amyloid A and haptoglobin), calculate species-specific biomarker worth ranges. In addition, we used opportunistically collected samples to analyze the concentrations of every biomarker throughout recognized scientific circumstances of sickness or damage, as a first step to understanding what biomarkers could also be helpful to managing elephant well being.

Immunity-Related GTPase Family M Protein (IRGM) Antibody

20-abx210849
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
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Immunity-Related GTPase Family M Protein (IRGM) Antibody

20-abx126951
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul
  • Shipped within 5-10 working days.

Immunity-Related GTPase Family Q Protein (IRGQ) Antibody

abx032348-400ul 400 ul
EUR 551
  • Shipped within 5-10 working days.

Immunity-Related GTPase Family Q Protein (IRGQ) Antibody

abx032348-80l 80 µl
EUR 321
  • Shipped within 5-10 working days.

Immunity-Related GTPase Family M Protein (IRGM) Protein

20-abx260986
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody

20-abx339551
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Immunity-Related GTPase Family Q Protein (IRGQ) Antibody

abx234399-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody

20-abx321743
  • EUR 300.00
  • EUR 244.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody

abx448534-100ug 100 ug
EUR 523
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (ALP)

abx448005-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (APC)

abx448006-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (Biotin)

abx448007-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (FITC)

abx448008-100ug 100 ug
EUR 565
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (HRP)

abx448009-100ug 100 ug
EUR 565
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (PerCP)

abx448011-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (RPE)

abx448012-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (Streptavidin)

abx448013-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

IRGM Immunity-Related GTPase Family, M Human Recombinant Protein

PROTA1A4Y4 Regular: 20ug
EUR 317
Description: IRGM Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 180 amino acids (23-181) and having a molecular mass of 20.1 kDa. IRGM is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Immunity Related GTPase M (IRGM) Antibody

abx412110-01mg 0.1 mg
EUR 537
  • Shipped within 1 week.

Human Immunity- related GTPase family Q protein, IRGQ ELISA KIT

ELI-13087h 96 Tests
EUR 824

Rat Immunity- related GTPase family M protein, Irgm ELISA KIT

ELI-20422r 96 Tests
EUR 886

Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 390)

abx447997-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 488)

abx447998-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 565)

abx447999-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 594)

abx448000-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 633)

abx448001-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 655)

abx448002-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 680)

abx448003-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 700)

abx448004-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Human Immunity-Related GTPase Family Q Protein (IRGQ) ELISA Kit

abx388031-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.

Human Immunity- related GTPase family M protein, IRGM ELISA KIT

ELI-48787h 96 Tests
EUR 824

Mouse Immunity- related GTPase family Q protein, Irgq ELISA KIT

ELI-48788m 96 Tests
EUR 865

Mouse Immunity- related GTPase family M protein 1, Irgm1 ELISA K

ELI-43703m 96 Tests
EUR 865

Immunity-Related GTPase Family M Protein (IRGM) Antibody (PE/ATTO 594)

abx448010-100ug 100 ug
EUR 592
  • Shipped within 5-12 working days.

Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-100ug

QP6236-ec-100ug 100ug
EUR 408

Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-10ug

QP6236-ec-10ug 10ug
EUR 200

Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-1mg

QP6236-ec-1mg 1mg
EUR 1632

Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-200ug

QP6236-ec-200ug 200ug
EUR 634

Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-500ug

QP6236-ec-500ug 500ug
EUR 1060

Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-50ug

QP6236-ec-50ug 50ug
EUR 263

Recombinant Human Rho Family GTPase 1

7-06157 5µg Ask for price

Recombinant Human Rho Family GTPase 1

7-06158 20µg Ask for price

Recombinant Human Rho Family GTPase 1

7-06159 1mg Ask for price

Recombinant Human Rho Family GTPase 3

7-06160 5µg Ask for price

Recombinant Human Rho Family GTPase 3

7-06161 20µg Ask for price

Recombinant Human Rho Family GTPase 3

7-06162 1mg Ask for price

DIRAS Family GTPase 3 (DIRAS3) Antibody

20-abx006587
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Rho Family GTPase 2 (RND2) Antibody

20-abx218322
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

DIRAS Family GTPase 3 (DIRAS3) Antibody

20-abx112094
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Rho Family Gtpase 2 (RND2) Antibody

20-abx115176
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Rho Family Gtpase 3 (RND3) Antibody

20-abx115177
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Rho Family GTPase 2 (RND2) Antibody

20-abx121211
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Rho Family GTPase 1 (RND1) Antibody

20-abx130669
  • EUR 411.00
  • EUR 133.00
  • EUR 1149.00
  • EUR 565.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Rho Family GTPase 1 (RND1) Antibody

abx145149-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

DIRAS Family GTPase 3 (DIRAS3) Antibody

abx032656-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

DIRAS Family GTPase 3 (DIRAS3) Antibody

abx032656-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

GTPase, IMAP Family Member 6 Protein

20-abx261940
  • EUR 4490.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

DIRAS Family GTPase 3 (DIRAS3) Antibody

20-abx339162
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

DIRAS Family GTPase 3 (DIRAS3) Antibody

20-abx320343
  • EUR 300.00
  • EUR 244.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Rho Family GTPase 2 (RND2) Antibody

abx237332-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

Rho Family GTPase 2 (RND2) Antibody

20-abx318052
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

DIRAS Family GTPase 3 (DIRAS3) Antibody

20-abx225145
  • EUR 370.00
  • EUR 606.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 50 ul
  • Shipped within 5-10 working days.

GTPase, IMAP Family Member 5 Protein

20-abx262699
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

Recombinant Rho Family GTPase 1 (RND1)

4-RPB788Hu01
  • EUR 377.76
  • EUR 204.00
  • EUR 1141.60
  • EUR 447.20
  • EUR 794.40
  • EUR 316.00
  • EUR 2704.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q92730
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 29.4kDa
  • Isoelectric Point: Inquire
Description: Recombinant Human Rho Family GTPase 1 expressed in: E.coli

GTPase IMAP Family Member 4 (GIMAP4) Antibody

20-abx008113
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 8 (GIMAP8) Antibody

abx027293-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 8 (GIMAP8) Antibody

abx027293-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 7 (GIMAP7) Antibody

20-abx216118
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 2 (GIMAP2) Antibody

20-abx112878
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 4 (GIMAP4) Antibody

20-abx112879
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 5 (GIMAP5) Antibody

20-abx112880
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 7 (GIMAP7) Antibody

20-abx112881
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 5 (GIMAP5) Antibody

20-abx124690
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 4 (GIMAP4) Antibody

abx146087-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Human Rho Family GTPase 1 (RND1) Protein

20-abx168764
  • EUR 537.00
  • EUR 244.00
  • EUR 1553.00
  • EUR 634.00
  • EUR 398.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

GTPase IMAP Family Member 2 (GIMAP2) Antibody

20-abx014508
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 4 (GIMAP4) Antibody

20-abx014509
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 5 (GIMAP5) Antibody

20-abx014510
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

Human Rho family GTPase 1 ELISA Kit

ELA-E1788h 96 Tests
EUR 824

GTPase IMAP Family Member 2 (GIMAP2) Antibody

abx233456-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

GTPase IMAP Family Member 4 (GIMAP4) Antibody

abx233457-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

GTPase IMAP Family Member 5 (GIMAP5) Antibody

abx233458-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

GTPase IMAP Family Member 7 (GIMAP7) Antibody

abx233459-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Rho Family GTPase 2 (RND2) Antibody (HRP)

20-abx315972
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Rho Family GTPase 2 (RND2) Antibody (FITC)

20-abx315973
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Rho Family GTPase 2 (RND2) Antibody (Biotin)

20-abx315974
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 2 (GIMAP2) Antibody

abx330512-100ul 100 ul
EUR 425
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 5 (GIMAP5) Antibody

abx330629-100ul 100 ul
EUR 425
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 4 (GIMAP4) Antibody

abx330973-100ul 100 ul
EUR 425
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 2 (GIMAP2) Antibody

20-abx324240
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 5 (GIMAP5) Antibody

20-abx324499
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 4 (GIMAP4) Antibody

20-abx324751
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

GTPase IMAP Family Member 7 (GIMAP7) Antibody

20-abx302667
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Recombinant human GTPase IMAP family member 1

P2329 100ug Ask for price
  • Uniprot ID: Q8WWP7
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for human GTPase IMAP family member 1

Human Tumor Immunity Primer Library

HTIMU-I 1 set
EUR 548

Mouse Tumor Immunity Primer Library

MTIMU-I 1 set
EUR 548

Secretion Associated Ras Related GTPase 1B (SAR1B) Antibody

abx025703-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Immune biomarkers had been every elevated above the calculated species-specific worth ranges in a minimum of one scientific case, however resulting from variability in each scientific and non-clinical samples, solely serum amyloid A was considerably greater in scientific in comparison with non-clinical paired samples, with tendencies for greater TNF-α and IL-10. We additionally detected elevated secretion of serum amyloid A and all 5 cytokines following routine vaccination of a single Asian elephant, indicating that these biomarkers will be helpful for finding out regular immune processes in addition to pathology. This research signifies that assays developed with industrial reagents can be utilized to quantify well being biomarkers in wildlife species and identifies a number of that warrant additional investigation to elucidate immune responses to varied pathologies.

Green preparation of hydrogel particles-in-emulsions for simultaneous enhancement of humoral and cell-mediated immunity

Green preparation of hydrogel particles-in-emulsions for simultaneous enhancement of humoral and cell-mediated immunity

Emulsions are one of essentially the most usually used vaccine adjuvant formulations. Although they promote excessive humoral immunity, the induced mobile immunity is commonly poor, which prohibit their utility. To improve the mobile immunity, some researchers have ready combined formulations by including particles into the aqueous part of emulsions. However, the particle preparation course of normally includes the addition and elimination of natural reagents, which is environmentally unfriendly and cumbersome. Moreover, the obtained vaccine adjuvant solely induces restricted cell-mediated immunity and humoral immunity in contrast with emulsion-adjuvanted vaccines.

Herein, we developed a inexperienced and easy technique for fabricating a novel nanoparticles-in-emulsions (NPE) formulation. Firstly, a temperature-sensitive hydrogel was used to organize particles by self-solidification with out extra crosslinking reagents. Secondly, the white oil was used as natural part to keep away from the particle washing procedures and natural solvent residues. Moreover, the impact of NPE as vaccine adjuvant was evaluated through the use of two veterinary vaccines as mannequin antigens. NPE confirmed benefits than the traditional vaccine formulations in inducing each humoral and mobile immunity. This work gives a facile and broadly relevant method for getting ready nanoparticles-in-emulsions formulation, and presents an efficient adjuvant for enhancing immunity in opposition to infectious ailments.

Effects of zearalenone on genital organ growth, serum immunoglobulin, antioxidant capability, intercourse hormones and liver operate of prepubertal gilts

The research aimed to look at the consequences of zearalenone on genital organ growth, serum immunoglobulin, antioxidant capability, intercourse hormones and liver operate of prepubertal gilts. Forty-eight prepubertal gilts (Landrace × Yorkshire) had been randomly divided into three therapy (T1, T2 and T3) teams and a management group (12 replicates per group, 1 gilt per replicate). Prepubertal gilts within the management group had been fed with basal food regimen, and these in T1, T2 and T3 teams had been fed with basal diets supplemented with 200 μg/kg, 800 μg/kg and 1600 μg/kg zearalenone in the course of the experiment interval, which lasted for 14 d. Feed consumption was counted and vulvar space was measured. The blood samples had been collected from the anterior vena cava of 6 prepubertal gilts in every group, and immunoglobulins, antioxidant indexes, inflammatory cytokines, genital hormones, and biochemical indexes had been analyzed by enzyme-linked immunosorbent assay.

The outcomes confirmed that the common every day feed consumption of prepubertal gilts in every group had no important change (p > 0.05). On 14 d, in contrast with the management group, the vulva space of prepubertal gilts in every therapy group was considerably elevated (p < 0.05). Compared with the management group, the serum immunoglobulin G content material within the T3 group was considerably lowered (p < 0.05). The actions of complete antioxidant capability and the superoxide dismutase of serum within the T3 group had been considerably lowered (p < 0.05). Compared with the management group, the serum interleukin-Four content material in every take a look at group had been extraordinarily considerably elevated (p < 0.01).

The serum contents of luteinizing hormone within the T2 and T3 teams and estradiol within the T3 group had been considerably lowered (p < 0.05) than that of management group. Compared with the management group, the exercise of aspartate aminotransferase in T3 group was considerably elevated (p < 0.05). In conclusion, zearalenone has no considerably impact on the feed consumption of prepubertal gilts, however it may cut back its serum immunoglobulin contents and antioxidant properties, disrupt the secretion of intercourse hormones, enhance the vulva space, produce reproductive toxicity and trigger liver harm. Therefore, in pig manufacturing, the use of antimould reagent along with merchandise of immunity-boosting, antioxidant, anti-inflammatory and hepatoprotective could improve safety.

 Green preparation of hydrogel particles-in-emulsions for simultaneous enhancement of humoral and cell-mediated immunity

A Novel In-Cell ELISA Assay Allows Rapid and Automated Quantification of SARS-CoV-2 to Analyze Neutralizing Antibodies and Antiviral Compounds

The coronavirus illness 2019 (COVID-19) brought on by the extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is presently essentially the most urgent medical and socioeconomic problem. Constituting essential correlates of safety, the willpower of virus-neutralizing antibodies (NAbs) is indispensable for convalescent plasma choice, vaccine candidate analysis, and immunity certificates. In distinction to plain serological ELISAs, plaque discount neutralization checks (PRNTs) are laborious, time-consuming, costly, and restricted to specialised laboratories.

To change microscopic counting-based SARS-CoV-2 PRNTs by a novel assay exempt from genetically modified viruses, that are inapplicable in most diagnostics departments, we established a easy, fast, and automated SARS-CoV-2 neutralization assay using an in-cell ELISA (icELISA) method. After optimization of varied parameters similar to virus-specific antibodies, cell strains, virus doses, and length of an infection, SARS-CoV-2-infected cells turned amenable as direct antigen supply for quantitative icELISA.

9998 SCREW CAP 400/24

9998-24 12/pk
EUR 54
Description: General Apparatus; Stoppers

9999 CAP ONLY 400/24

9999-24 12/pk
EUR 50
Description: General Apparatus; Stoppers

Aligned Nanofibers 24 Well Plate Inserts

3D00016-24 700 nm-PCLs
EUR 110

Recombinant human Innate immunity activator protein

P1297 100ug Ask for price
  • Uniprot ID: Q3KP66
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for human Innate immunity activator protein

24 WELL PCR MICROPLATE. CLEAR

PCR-24-C 10/pk
EUR 73
Description: PCR Plates & Tubes; PCR Strip Tubes and Strip Caps - Axygen

PIERCABLE SEALING MAT FOR 24 WELL DEEP WELL PLATE

AM-24-SQ 10/pk
EUR 207
Description: Sealing Products; Sealing mats - Axygen

IL-24 Interleukin-24 Human Recombinant Protein

PROTQ13007 Regular: 10ug
EUR 317
Description: Interleukin 24 human recombinant produced in yeast is a single, glycosylated, polypeptide chain containing 158 amino acids and having a molecular mass of 18 kDa. As a result of glycosylation, the protein migrates at 19.5 kDa on SDS-PAGE.

IRGM Immunity-Related GTPase Family, M Human Recombinant Protein

PROTA1A4Y4 Regular: 20ug
EUR 317
Description: IRGM Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 180 amino acids (23-181) and having a molecular mass of 20.1 kDa. IRGM is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Recombinant Human IL-24 Protein

PROTQ13007-1 20ug
EUR 317
Description: IL-24 is a secreted glycoprotein belonging to the IL-10 structural family of cytokines. It is produced by a variety of cell types, including B cells, CD4+ cells, NK cells, lymph node DCs, monocytes, and melanoma cells. IL-24 can signal through the IL20R1/IL20R2 and IL22R1/IL20R2 receptors to initiate a signaling cascade which includes the induction of JAK1/STAT3 phosphorylation. IL-24 is, functionally, a pleiotropic protein but is generally characterized as an anti-cancer cytokine that can selectively inhibit growth of a wide variety of human cancer cells through activities that include the induction of differentiation and apoptosis, and the suppression of angiogenesis and cell proliferation. Recombinant human IL-24 is an 18.9 kDa glycoprotein, containing 161 amino acid residues, including a C-terminal His-tag.

Canine IL-24 Recombinant Protein

R03793 5ug/vial
EUR 259
Description: Interleukin 24 (IL-24), also known as mda-7, is a member of the IL-10 family of cytokines. IL-24 performs important roles in wound healing, psoriasis and cancer. Canine IL-24 Recombinant Protein is purified interleukin-24 produced in yeast.

RNU6-24 Recombinant Protein (Human)

RP089061 100 ug Ask for price

Recombinant HPV-24 E1 Protein

VAng-Wyb3108-inquire inquire Ask for price
Description: Human papillomavirus type 24 Replication protein E1, recombinant protein.

Recombinant HPV-24 L1 Protein

VAng-Wyb3112-inquire inquire Ask for price
Description: Human papillomavirus type 24 Major capsid protein L1, recombinant protein.

Recombinant HPV-24 L2 Protein

VAng-Wyb3113-inquire inquire Ask for price
Description: Human papillomavirus type 24 Minor capsid protein L2, recombinant protein.

Recombinant Escherichia coli Colicin-Ia immunity Protein (aa 1-111)

VAng-Lsx02230-inquire inquire Ask for price
Description: Escherichia coli Colicin-Ia immunity protein, recombinant protein.

Recombinant Escherichia coli Colicin-Ia immunity Protein (aa 1-32)

VAng-Lsx02231-1mgEcoli 1 mg (E. coli)
EUR 2938
Description: Escherichia coli Colicin-Ia immunity protein (aa 1-32), recombinant protein.

Recombinant Escherichia coli Colicin-Ia immunity Protein (aa 1-32)

VAng-Lsx02231-500gEcoli 500 µg (E. coli)
EUR 2223
Description: Escherichia coli Colicin-Ia immunity protein (aa 1-32), recombinant protein.

Recombinant Escherichia coli Colicin-Ib immunity Protein (aa 1-115)

VAng-Lsx02232-inquire inquire Ask for price
Description: Escherichia coli Colicin-Ib immunity protein, recombinant protein.

CA72-4 ELISA test

24 96T/Box Ask for price
  • Area of application: Hormone testing
Description: ELISA based test for quantitative detection of CA72-4

PIERCABLE SEALING MAT FOR 24 WELL DEEP WELL PLATE, STERILE

AM-24-SQ-S 10/pk
EUR 234
Description: Sealing Products; Sealing mats - Axygen

Mouse pre-microRNA Expression Construct mir-24-1

MMIR-24-1-PA-1 Bacterial Streak
EUR 684
  • Category: MicroRNA Tools

Mouse pre-microRNA Expression Construct mir-24-2

MMIR-24-2-PA-CL Bacterial Streak
EUR 684
  • Category: MicroRNA Tools

Human Tumor Immunity Primer Library

HTIMU-I 1 set
EUR 548

Mouse Tumor Immunity Primer Library

MTIMU-I 1 set
EUR 548

ID-VAC Human Influenza A Vaccine identification ELISA kit, 24 tests

920-FLA-VID-24 1 Kit
EUR 529

ID-VAC Human Anti-Influenza B Vaccine ELISA kit, 24 tests

920-FLB-VID-24 1 Kit
EUR 529

Immunity-Related GTPase Family M Protein (IRGM) Protein

20-abx260986
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-100ug

QP6236-ec-100ug 100ug
EUR 408

Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-10ug

QP6236-ec-10ug 10ug
EUR 200

Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-1mg

QP6236-ec-1mg 1mg
EUR 1632

Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-200ug

QP6236-ec-200ug 200ug
EUR 634

Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-500ug

QP6236-ec-500ug 500ug
EUR 1060

Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-50ug

QP6236-ec-50ug 50ug
EUR 263

ID-Vac? Meningococcal Vaccines (A/C/W/Y) Identification Kit, 24 tests

600-MEN-VID-24 1 Kit
EUR 529

Recombinant Human Vacuolar Protein Sorting 24

7-06868 5µg Ask for price

Recombinant Human Vacuolar Protein Sorting 24

7-06869 20µg Ask for price

Recombinant Human Vacuolar Protein Sorting 24

7-06870 1mg Ask for price

Recombinant human RNA-binding protein 24

P2286 100ug Ask for price
  • Uniprot ID: Q9BX46
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for human RNA-binding protein 24

Recombinant Human Interleukin-24

7-01081 2µg Ask for price

Recombinant Human Interleukin-24

7-01082 10µg Ask for price

Recombinant Human Interleukin-24

7-01083 1mg Ask for price

IL-24, human recombinant

4975-10
EUR 365

IL-24, human recombinant

4975-100
EUR 1414

IL-24, human recombinant

4975-1000
EUR 10810

Recombinant Human Interleukin-24

CC072-002 2ug
EUR 293

Recombinant Human Interleukin-24

CC072-010 10ug
EUR 408

Recombinant Human Interleukin-24

CC072-101 1mg
EUR 10310

Recombinant human Cadherin-24

P1413 100ug Ask for price
  • Uniprot ID: Q86UP0
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for human Cadherin-24

Recombinant Interleukin 24 (IL24)

4-RPC064Hu01
  • EUR 548.00
  • EUR 250.00
  • EUR 1780.00
  • EUR 660.00
  • EUR 1220.00
  • EUR 430.00
  • EUR 4300.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q13007
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 19.5kDa
  • Isoelectric Point: 8.6
Description: Recombinant Human Interleukin 24 expressed in: E.coli

Recombinant Interleukin 24 (IL24)

4-RPC064Ra01
  • EUR 583.84
  • EUR 259.00
  • EUR 1914.40
  • EUR 704.80
  • EUR 1309.60
  • EUR 454.00
  • EUR 4636.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q9JI24
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 48.0kDa
  • Isoelectric Point: 8.4
Description: Recombinant Rat Interleukin 24 expressed in: E.coli

ID-VAC H. Influenzae B (Hib-PRP) vaccine Identification ELISA Kit, 24 tests

980-Hib-VID-24 1 Kit
EUR 529

Human Immunity-related GTPase family M protein (IRGM)

1-CSB-EP011827HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 47.1 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Immunity-related GTPase family M protein(IRGM) expressed in E.coli

Immunity-Related GTPase Family M Protein (IRGM) Antibody

abx026104-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody

abx026104-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody

20-abx210849
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody

20-abx126951
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul
  • Shipped within 5-10 working days.

Immunity-Related GTPase Family Q Protein (IRGQ) Antibody

abx032348-400ul 400 ul
EUR 551
  • Shipped within 5-10 working days.

Immunity-Related GTPase Family Q Protein (IRGQ) Antibody

abx032348-80l 80 µl
EUR 321
  • Shipped within 5-10 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody

20-abx339551
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Immunity-Related GTPase Family Q Protein (IRGQ) Antibody

abx234399-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody

20-abx321743
  • EUR 300.00
  • EUR 244.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody

abx448534-100ug 100 ug
EUR 523
  • Shipped within 5-12 working days.

Immunity Related GTPase M (IRGM) Antibody

abx412110-01mg 0.1 mg
EUR 537
  • Shipped within 1 week.

Recombinant Escherichia coli Colicin-E5 immunity protein in ColE9 (aa 1-83)

VAng-Lsx02228-1mgEcoli 1 mg (E. coli)
EUR 2759
Description: Escherichia coli Colicin-E5 immunity protein in ColE9, recombinant protein.

Recombinant Escherichia coli Colicin-E5 immunity protein in ColE9 (aa 1-83)

VAng-Lsx02228-500gEcoli 500 µg (E. coli)
EUR 1961
Description: Escherichia coli Colicin-E5 immunity protein in ColE9, recombinant protein.

Recombinant Escherichia coli Colicin-E5 immunity protein in ColE9 (aa 1-83)

VAng-Lsx02228-50gEcoli 50 µg (E. coli)
EUR 1356
Description: Escherichia coli Colicin-E5 immunity protein in ColE9, recombinant protein.

Recombinant Mycobacterium Tuberculosis PstS 1 Protein (aa 24-374, aa 24-373)

VAng-Yyj0150-10g 10 µg
EUR 775
Description: Mycobacterium Tuberculosis Phosphate-binding protein PstS 1, recombinant protein.

Recombinant human Ras-related protein Rab-24

P2228 100ug Ask for price
  • Uniprot ID: Q969Q5
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for human Ras-related protein Rab-24

Recombinant EpCAM Protein (Gln 24-Lys 265)

VAng-1489Lsx-200g 200 µg
EUR 3487
Description: Biotinylated Human EpCAM is expressed in HEK 293 cells. (Uniprot ID: AAH14785.1)

Recombinant EpCAM Protein (Gln 24-Lys 265)

VAng-1489Lsx-25g 25 µg
EUR 848
Description: Biotinylated Human EpCAM is expressed in HEK 293 cells. (Uniprot ID: AAH14785.1)

VPS24 Vacuolar Protein Sorting 24 Human Recombinant Protein

PROTQ9Y3E7 Regular: 20ug
EUR 317
Description: VPS24 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 242 amino acids (1-222 a.a) and having a molecular mass of 27.2kDa (Molecular weight on SDS-PAGE will appear higher).;VPS24 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Recombinant Matrix Metalloproteinase 24 (MMP24)

4-RPB894Hu01
  • EUR 519.33
  • EUR 242.00
  • EUR 1672.48
  • EUR 624.16
  • EUR 1148.32
  • EUR 410.00
  • EUR 4031.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q9Y5R2
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 28.7kDa
  • Isoelectric Point: 9.1
Description: Recombinant Human Matrix Metalloproteinase 24 expressed in: E.coli

Immunity-Related GTPase Family M Protein (IRGM) Antibody (ALP)

abx448005-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (APC)

abx448006-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (Biotin)

abx448007-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (FITC)

abx448008-100ug 100 ug
EUR 565
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (HRP)

abx448009-100ug 100 ug
EUR 565
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (PerCP)

abx448011-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (RPE)

abx448012-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

Immunity-Related GTPase Family M Protein (IRGM) Antibody (Streptavidin)

abx448013-100ug 100 ug
EUR 578
  • Shipped within 5-12 working days.

VAC-ID Gardasil Human Papilloma Virus Vaccine (Quadrivalent 6+11+16+18) identification ELISA kit, 24 tests

550-HPV-VID-24 1 Kit Ask for price

ID-VAC VacciGel Direct ELISA for the identification of Diphtheria Toxoid Vaccine (DTX) formulated in Alum, 24 tests

VAC-DTX-VID-24 1 Kit
EUR 529

ID-VAC VacciGel Direct ELISA for the identification of Hepatitis B Vaccine (HBsAg) formulated in Alum, 24 tests

VAC-HBS-VID-24 1 Kit
EUR 529

ID-VAC VacciGel Direct ELISA for the identification of Tetanus Toxoid Vaccine (TTX) formulated in Alum, 24 tests

VAC-TTX-VID-24 1 Kit
EUR 529

Interleukin 24 (IL-24) Antibody

abx234257-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

Interleukin 24 (IL-24) Antibody

abx234258-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

ID-VAC VacciGel Direct ELISA for the identification of B. Pertussis Toxoid Vaccine (PTX) formulated in Alum, 24 tests

VAC-PTX-VID-24 1 Kit
EUR 529

Recombinant Shigella Sonnei yaaI Protein (aa 24-134)

VAng-0311Lsx-1mgEcoli 1 mg (E. coli)
EUR 3103
Description: Shigella Sonnei (strain Ss046) UPF0412 protein yaaI, recombinant protein.

Recombinant Shigella Sonnei yaaI Protein (aa 24-134)

VAng-0311Lsx-500gEcoli 500 µg (E. coli)
EUR 2085
Description: Shigella Sonnei (strain Ss046) UPF0412 protein yaaI, recombinant protein.

Recombinant Shigella Sonnei yaaI Protein (aa 24-134)

VAng-0311Lsx-50gEcoli 50 µg (E. coli)
EUR 1439
Description: Shigella Sonnei (strain Ss046) UPF0412 protein yaaI, recombinant protein.

Recombinant Toxoplasma Gondii GRA2 Protein (aa 24-185)

VAng-0423Lsx-1mgEcoli 1 mg (E. coli)
EUR 3239
Description: Toxoplasma Gondii Dense granule protein 2, recombinant protein.

Recombinant Toxoplasma Gondii GRA2 Protein (aa 24-185)

VAng-0423Lsx-500gEcoli 500 µg (E. coli)
EUR 2319
Description: Toxoplasma Gondii Dense granule protein 2, recombinant protein.

Recombinant Toxoplasma Gondii GRA2 Protein (aa 24-185)

VAng-0423Lsx-50gEcoli 50 µg (E. coli)
EUR 1590
Description: Toxoplasma Gondii Dense granule protein 2, recombinant protein.

Recombinant Toxoplasma Gondii MIC6 Protein (aa 24-349)

VAng-0441Lsx-100g 100 µg
EUR 6608
Description: Toxoplasma Gondii Micronemal protein 6, recombinant protein.

Recombinant Toxoplasma Gondii MIC6 Protein (aa 24-349)

VAng-0441Lsx-50g 50 µg
EUR 4064
Description: Toxoplasma Gondii Micronemal protein 6, recombinant protein.

Recombinant Toxoplasma Gondii p29 Protein (aa 24-100)

VAng-0454Lsx-100g 100 µg
EUR 598
Description: Toxoplasma Gondii p29 (GRA7), recombinant protein from E. coli.

Recombinant Toxoplasma Gondii p29 Protein (aa 24-100)

VAng-0454Lsx-500g 500 µg
EUR 2247
Description: Toxoplasma Gondii p29 (GRA7), recombinant protein from E. coli.

Recombinant ASFV Ba71V-056 Protein (aa 24-152)

VAng-0748Lsx-1mg 1 mg
EUR 3225
Description: African swine fever virus (strain Badajoz 1971 Vero-adapted) Uncharacterized protein EP152R (Ba71V-056), recombinant protein from E. coli. (Uniprot ID: Q65149)

Antiviral brokers similar to human sera containing NAbs or antiviral interferons dose dependently lowered the SARS-CoV-2-specific sign. Applying elevated infectious doses, the icELISA-based neutralization take a look at (icNT) was superior to PRNT in discriminating convalescent sera with excessive from these with intermediate neutralizing capacities. In addition, the icNT was discovered to be particular, discriminating between SARS-CoV-2-specific NAbs and these raised in opposition to different coronaviruses. Altogether, the SARS-CoV-2 icELISA take a look at permits fast (<48 h in complete, read-out in seconds) and automated quantification of virus an infection in cell tradition to guage the efficacy of NAbs and antiviral medicine utilizing reagents and tools current in most routine diagnostics departments.

Using nanoparticles for in situ vaccination against cancer: mechanisms and immunotherapy benefits

Using nanoparticles for in situ vaccination against cancer: mechanisms and immunotherapy benefits

Immunotherapy to deal with most cancers is now a longtime scientific strategy. Immunotherapy may be utilized systemically, as accomplished with checkpoint blockade antibodies, but it surely can be injected straight into recognized tumors, in a method of in situ vaccination (ISV). ISV is designed to stimulate a robust native antitumor immune response involving each innate and adaptive immune cells, and via this generate a systemic antitumor immune response against metastatic tumors. Quite a lot of ISVs have been utilized to generate an immunostimulatory tumor microenvironment (TME).

These embody attenuated microorganisms, recombinant proteins, small molecules, bodily disruptors of TME (alternating magnetic and centered ultrasound heating, photothermal remedy, and radiotherapy), and extra not too long ago nanoparticles (NPs). NPs are engaging and distinctive since they will load a number of medicine or different reagents to affect immune and most cancers cell capabilities in the TME, affording a novel alternative to stimulate antitumor immunity. Here, we describe the NP-ISV therapeutic mechanisms, assessment chemically synthesized NPs (i.e., liposomes, polymeric, chitosan-based, inorganic NPs, and so forth.), biologically derived NPs (virus and bacteria-based NPs), and energy-activated NP-ISVs in the context of their use as native ISV. Data means that NP-ISVs can improve outcomes of immunotherapeutic regimens together with these using tumor hyperthermia and checkpoint blockade therapies.

The complement system is a conserved element of innate immunity that fulfills numerous roles in protection and homeostasis. Inappropriate activation of complement contributes to many inflammatory illnesses, nonetheless, which has led to a renewed emphasis on improvement of therapeutic complement inhibitors. Activation of complement element C3 is required for amplification of complement and is achieved via two multisubunit proteases known as C3 convertases. Of these, the choice pathway (AP) C3 convertase is accountable for a majority of the C3 activation merchandise in vivo, which renders it a gorgeous goal for inhibitor discovery.

In this research, we report the identification and characterization of two associated sluggish off-rate modified DNA aptamers (SOMAmer) reagents that inhibit formation of the AP C3 convertase by binding to the proprotease, issue B (FB). These aptamers, often known as SL1102 (31 bases) and SL1103 (29 bases), comprise uniform substitutions of 5-(N-2-naphthylethylcarboxyamide)-2′-deoxyuridine for deoxythymidine. SL1102 and SL1103 bind FB with Ok d values of 49 and 88 pM, respectively, and inhibit activation of C3 and lysis of rabbit erythrocytes beneath AP-specific circumstances.

Cocrystal buildings of SL1102 (3.four Å) and SL1103 (3.1 Å) certain to human FB revealed that SL1102 and SL1103 acknowledge a web site on the juncture of the CCP1, CCP3, and vWF domains of FB. Consistent with these buildings and beforehand revealed data, these aptamers inhibited FB binding to C3b and blocked formation of the AP C3 convertase. Together, these outcomes show potent AP inhibition by modified DNA aptamers and increase the pipeline of FB-binding molecules with favorable pharmacologic properties.

Higher-Order Structure Characterization of NKG2A/CD94 Protein Complex and Anti-NKG2A Antibody Binding Epitopes by Mass Spectrometry-Based Protein Footprinting Strategies

NK group 2 member A (NKG2A), an immune checkpoint inhibitor, is an rising therapeutic goal in immuno-oncology. NKG2A kinds a heterodimer with CD94 on the cell floor of NK and a subset of T cells and acknowledges the nonclassical human leukocyte antigen (HLA-E) in people. Therapeutic blocking antibodies that block the ligation between HLA-E and NKG2A/CD94 have been proven to boost antitumor immunity in mice and people. In this research, we illustrate the sensible utilities of mass spectrometry (MS)-based protein footprinting in areas from reagent characterization to antibody epitope mapping.

Hydrogen/deuterium trade mass spectrometry (HDX-MS) in the higher-order construction characterization of NKG2A in complicated with CD94 offers novel insights into the conformational dynamics of NKG2A/CD94 heterodimer. To absolutely perceive antibody/goal interactions, we employed complementary protein footprinting strategies, together with HDX-MS and quick photochemical oxidation of proteins (FPOP)-MS, to find out the binding epitopes of therapeutic monoclonal antibodies focusing on NKG2A. Such a mix strategy offers molecular insights into the binding mechanisms of antibodies to NKG2A with excessive specificity, demonstrating the blockade of NKG2A/HLA-E interplay.

 Using nanoparticles for in situ vaccination against cancer: mechanisms and immunotherapy benefits

Generation of Human iPSCs by Protein Reprogramming and Stimulation of TLR3 Signaling

The discovery of induced pluripotent stem cells (iPSCs) permits for institution of human embryonic stem-like cells from numerous grownup human somatic cells (e.g., fibroblasts), with out the necessity for destruction of human embryos. This offers an unprecedented alternative the place patient-specific iPSCs may be subsequently differentiated to many cell varieties, e.g., cardiac cells and neurons, in order that we will use these iPSC-derived cells to check patient-specific illness mechanisms and conduct drug testing and screening. Critically, these cells have limitless therapeutic potentials, and there are lots of ongoing scientific trials to analyze the regenerative potentials of those iPSC-derivatives in people. However, the standard iPSC reprogramming strategies have drawback of insertional mutagenesis due to use of the integrating viral vectors.

Recombinant Human Transcription Factor-A

7-06637 1µg Ask for price

Recombinant Human Transcription Factor-A

7-06638 5µg Ask for price

Recombinant Human Transcription Factor-A

7-06639 50µg Ask for price

Human Tumor Immunity Primer Library

HTIMU-I 1 set
EUR 548

Mouse Tumor Immunity Primer Library

MTIMU-I 1 set
EUR 548

Recombinant Human Epidermal Growth Factor (a. a. 53)

DAG300 0.5mg
EUR 762

IRGM Immunity-Related GTPase Family, M Human Recombinant Protein

PROTA1A4Y4 Regular: 20ug
EUR 317
Description: IRGM Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 180 amino acids (23-181) and having a molecular mass of 20.1 kDa. IRGM is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Recombinant Transcription Factor A, Mitochondrial (TFAM)

4-RPH050Hu01
  • EUR 508.58
  • EUR 239.00
  • EUR 1632.16
  • EUR 610.72
  • EUR 1121.44
  • EUR 403.00
  • EUR 3930.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q00059
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 51.4kDa
  • Isoelectric Point: Inquire
Description: Recombinant Human Transcription Factor A, Mitochondrial expressed in: E.coli

Recombinant Transcription Factor A, Mitochondrial (TFAM)

4-RPH050Mu01
  • EUR 583.84
  • EUR 259.00
  • EUR 1914.40
  • EUR 704.80
  • EUR 1309.60
  • EUR 454.00
  • EUR 4636.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P40630
  • Buffer composition: 100mMNaHCO3, 500mMNaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 53.6kDa
  • Isoelectric Point: 9.1
Description: Recombinant Mouse Transcription Factor A, Mitochondrial expressed in: E.coli

Recombinant Transcription Factor A, Mitochondrial (TFAM)

4-RPH050Ra01
  • EUR 592.80
  • EUR 262.00
  • EUR 1948.00
  • EUR 716.00
  • EUR 1332.00
  • EUR 460.00
  • EUR 4720.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q91ZW1
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 50.4kDa
  • Isoelectric Point: Inquire
Description: Recombinant Rat Transcription Factor A, Mitochondrial expressed in: E.coli

Recombinant Nuclear Factor I/A (NFIA)

4-RPC655Hu01
  • EUR 458.40
  • EUR 226.00
  • EUR 1444.00
  • EUR 548.00
  • EUR 996.00
  • EUR 370.00
  • EUR 3460.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q12857
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 20.8kDa
  • Isoelectric Point: Inquire
Description: Recombinant Human Nuclear Factor I/A expressed in: E.coli

Immunity Related GTPase M (IRGM) Antibody

abx412110-01mg 0.1 mg
EUR 537
  • Shipped within 1 week.

Recombinant Human Vascular Endothelial Growth Factor (a. a. 165)

DAG304 10ug
EUR 748

Recombinant Escherichia coli Colicin-Ia immunity Protein (aa 1-111)

VAng-Lsx02230-inquire inquire Ask for price
Description: Escherichia coli Colicin-Ia immunity protein, recombinant protein.

Recombinant Escherichia coli Colicin-Ia immunity Protein (aa 1-32)

VAng-Lsx02231-1mgEcoli 1 mg (E. coli)
EUR 2938
Description: Escherichia coli Colicin-Ia immunity protein (aa 1-32), recombinant protein.

Recombinant Escherichia coli Colicin-Ia immunity Protein (aa 1-32)

VAng-Lsx02231-500gEcoli 500 µg (E. coli)
EUR 2223
Description: Escherichia coli Colicin-Ia immunity protein (aa 1-32), recombinant protein.

Recombinant Escherichia coli Colicin-Ib immunity Protein (aa 1-115)

VAng-Lsx02232-inquire inquire Ask for price
Description: Escherichia coli Colicin-Ib immunity protein, recombinant protein.

Goat Anti-Human recombinant Fetuin A (Alpha-2 HS-Glycoprotein, AHSG, A2HS) IgG

FETB12-A 100 ug
EUR 482

Goat Anti-Human Apolipoprotein A-IV A(ApoA4) peptid IgG, aff pure

APOA45-A 100 ul
EUR 482

Rabbit Anti-human MART-1/Melanocyte Differentiation-A/Melan-A peptide (CT) IgG

MART12-A 100 ul
EUR 445

Recombinant Human Fibroblast Growth Factor 2 (Basic) (a. a. 155)

DAG302 50ug
EUR 748

PDGF-A Platelet-Derived Growth Factor A Human Recombinant Protein

PROTP04085-2 Regular: 20ug
EUR 317
Description: Platelet-Derived Growth Factor A Human Recombinant short chain produced in E.Coli is a non-glycosylated, polypeptide chain containing 110 amino acids fragment (87-196) and having a total Mw of 17.02kDa, with an amino-terminal hexahistidine tag. ;PDGF-A is purified by proprietary chromatographic techniques.

HGF-A Hepatocyte Growth Factor A Chain Human Recombinant Protein

PROTP14210-4 Regular: 10ug
EUR 317
Description: HGF-A Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 463 amino acids fragment (32-494) having a total molecular weight of 57.8kDa. The HGF-A is fused with a 4.5kDa amino-terminal hexahistidine tag.;The HGF-A is purified by proprietary chromatographic techniques.

Mating Factor a

H-7724.0001 1.0mg
EUR 96
Description: Sum Formula: C82H114N20O17S; CAS# [59401-28-4] net

Mating Factor a

H-2925.0001 1.0mg
EUR 126
Description: Sum Formula: C82H114N20O17S; CAS# [59401-28-4] net

Mating Factor a

H-2925.0005 5.0mg
EUR 418
Description: Sum Formula: C82H114N20O17S; CAS# [59401-28-4] net

Boc-a-Me-DL-Val-OH

A-4145.0001 1.0g
EUR 139
Description: Sum Formula: C11H21NO4; CAS# [139938-00-4]

Boc-a-Me-DL-Val-OH

A-4145.0005 5.0g
EUR 477
Description: Sum Formula: C11H21NO4; CAS# [139938-00-4]

Recombinant Human Hepatocyte Growth Factor A Chain

7-00631 2µg Ask for price

Recombinant Human Hepatocyte Growth Factor A Chain

7-00632 10µg Ask for price

Recombinant Human Hepatocyte Growth Factor A Chain

7-00633 1mg Ask for price

Recombinant Human Platelet Derived Growth Factor-A

7-01351 5µg Ask for price

Recombinant Human Platelet Derived Growth Factor-A

7-01352 20µg Ask for price

Recombinant Human Platelet Derived Growth Factor-A

7-01353 1mg Ask for price

Recombinant Human Platelet Derived Growth Factor-A

CG093-005 5ug
EUR 293

Recombinant Human Platelet Derived Growth Factor-A

CG093-020 20ug
EUR 408

Recombinant Human Platelet Derived Growth Factor-A