Immunotherapy to deal with most cancers is now a longtime scientific strategy. Immunotherapy may be utilized systemically, as accomplished with checkpoint blockade antibodies, but it surely can be injected straight into recognized tumors, in a method of in situ vaccination (ISV). ISV is designed to stimulate a robust native antitumor immune response involving each innate and adaptive immune cells, and via this generate a systemic antitumor immune response against metastatic tumors. Quite a lot of ISVs have been utilized to generate an immunostimulatory tumor microenvironment (TME).
These embody attenuated microorganisms, recombinant proteins, small molecules, bodily disruptors of TME (alternating magnetic and centered ultrasound heating, photothermal remedy, and radiotherapy), and extra not too long ago nanoparticles (NPs). NPs are engaging and distinctive since they will load a number of medicine or different reagents to affect immune and most cancers cell capabilities in the TME, affording a novel alternative to stimulate antitumor immunity. Here, we describe the NP-ISV therapeutic mechanisms, assessment chemically synthesized NPs (i.e., liposomes, polymeric, chitosan-based, inorganic NPs, and so forth.), biologically derived NPs (virus and bacteria-based NPs), and energy-activated NP-ISVs in the context of their use as native ISV. Data means that NP-ISVs can improve outcomes of immunotherapeutic regimens together with these using tumor hyperthermia and checkpoint blockade therapies.
The complement system is a conserved element of innate immunity that fulfills numerous roles in protection and homeostasis. Inappropriate activation of complement contributes to many inflammatory illnesses, nonetheless, which has led to a renewed emphasis on improvement of therapeutic complement inhibitors. Activation of complement element C3 is required for amplification of complement and is achieved via two multisubunit proteases known as C3 convertases. Of these, the choice pathway (AP) C3 convertase is accountable for a majority of the C3 activation merchandise in vivo, which renders it a gorgeous goal for inhibitor discovery.
In this research, we report the identification and characterization of two associated sluggish off-rate modified DNA aptamers (SOMAmer) reagents that inhibit formation of the AP C3 convertase by binding to the proprotease, issue B (FB). These aptamers, often known as SL1102 (31 bases) and SL1103 (29 bases), comprise uniform substitutions of 5-(N-2-naphthylethylcarboxyamide)-2′-deoxyuridine for deoxythymidine. SL1102 and SL1103 bind FB with Ok d values of 49 and 88 pM, respectively, and inhibit activation of C3 and lysis of rabbit erythrocytes beneath AP-specific circumstances.
Cocrystal buildings of SL1102 (3.four Å) and SL1103 (3.1 Å) certain to human FB revealed that SL1102 and SL1103 acknowledge a web site on the juncture of the CCP1, CCP3, and vWF domains of FB. Consistent with these buildings and beforehand revealed data, these aptamers inhibited FB binding to C3b and blocked formation of the AP C3 convertase. Together, these outcomes show potent AP inhibition by modified DNA aptamers and increase the pipeline of FB-binding molecules with favorable pharmacologic properties.
Higher-Order Structure Characterization of NKG2A/CD94 Protein Complex and Anti-NKG2A Antibody Binding Epitopes by Mass Spectrometry-Based Protein Footprinting Strategies
NK group 2 member A (NKG2A), an immune checkpoint inhibitor, is an rising therapeutic goal in immuno-oncology. NKG2A kinds a heterodimer with CD94 on the cell floor of NK and a subset of T cells and acknowledges the nonclassical human leukocyte antigen (HLA-E) in people. Therapeutic blocking antibodies that block the ligation between HLA-E and NKG2A/CD94 have been proven to boost antitumor immunity in mice and people. In this research, we illustrate the sensible utilities of mass spectrometry (MS)-based protein footprinting in areas from reagent characterization to antibody epitope mapping.
Hydrogen/deuterium trade mass spectrometry (HDX-MS) in the higher-order construction characterization of NKG2A in complicated with CD94 offers novel insights into the conformational dynamics of NKG2A/CD94 heterodimer. To absolutely perceive antibody/goal interactions, we employed complementary protein footprinting strategies, together with HDX-MS and quick photochemical oxidation of proteins (FPOP)-MS, to find out the binding epitopes of therapeutic monoclonal antibodies focusing on NKG2A. Such a mix strategy offers molecular insights into the binding mechanisms of antibodies to NKG2A with excessive specificity, demonstrating the blockade of NKG2A/HLA-E interplay.
Generation of Human iPSCs by Protein Reprogramming and Stimulation of TLR3 Signaling
The discovery of induced pluripotent stem cells (iPSCs) permits for institution of human embryonic stem-like cells from numerous grownup human somatic cells (e.g., fibroblasts), with out the necessity for destruction of human embryos. This offers an unprecedented alternative the place patient-specific iPSCs may be subsequently differentiated to many cell varieties, e.g., cardiac cells and neurons, in order that we will use these iPSC-derived cells to check patient-specific illness mechanisms and conduct drug testing and screening. Critically, these cells have limitless therapeutic potentials, and there are lots of ongoing scientific trials to analyze the regenerative potentials of those iPSC-derivatives in people. However, the standard iPSC reprogramming strategies have drawback of insertional mutagenesis due to use of the integrating viral vectors.
) Recombinant Human Innate immunity activator protein (INAVA) |
|
CSB-YP662049HU |
Cusabio |
6526 mg |
Ask for price |
) Recombinant Human Immunity-related GTPase family M protein (IRGM) |
|
CSB-EP011827HU |
Cusabio |
1511 mg |
Ask for price |
) Recombinant Human Immunity-related GTPase family M protein(IRGM) |
|
AP76842 |
SAB |
1mg |
EUR 1978 |
|
|
 IRGM Immunity-Related GTPase Family, M Human Recombinant Protein |
|
PROTA1A4Y4 |
BosterBio |
Regular: 20ug |
EUR 380.4 |
|
Description: IRGM Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 180 amino acids (23-181) and having a molecular mass of 20.1 kDa. IRGM is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
) Recombinant Escherichia coli Colicin-Ia immunity Protein (aa 1-111) |
|
VAng-Lsx02230-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Escherichia coli Colicin-Ia immunity protein, recombinant protein. |
) Recombinant Escherichia coli Colicin-Ia immunity Protein (aa 1-32) |
|
VAng-Lsx02231-1mgEcoli |
Creative Biolabs |
1 mg (E. coli) |
EUR 3525.6 |
|
Description: Escherichia coli Colicin-Ia immunity protein (aa 1-32), recombinant protein. |
Recombinant Escherichia coli Colicin-Ia immunity Protein (aa 1-32) |
|
VAng-Lsx02231-500gEcoli |
Creative Biolabs |
500 µg (E. coli) |
EUR 2667.6 |
|
Description: Escherichia coli Colicin-Ia immunity protein (aa 1-32), recombinant protein. |
) Recombinant Escherichia coli Colicin-Ib immunity Protein (aa 1-115) |
|
VAng-Lsx02232-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Escherichia coli Colicin-Ib immunity protein, recombinant protein. |
) Recombinant Escherichia coli Colicin-E5 immunity protein in ColE9 (aa 1-83) |
|
VAng-Lsx02228-1mgEcoli |
Creative Biolabs |
1 mg (E. coli) |
EUR 3310.8 |
|
Description: Escherichia coli Colicin-E5 immunity protein in ColE9, recombinant protein. |
Recombinant Escherichia coli Colicin-E5 immunity protein in ColE9 (aa 1-83) |
|
VAng-Lsx02228-500gEcoli |
Creative Biolabs |
500 µg (E. coli) |
EUR 2353.2 |
|
Description: Escherichia coli Colicin-E5 immunity protein in ColE9, recombinant protein. |
Recombinant Escherichia coli Colicin-E5 immunity protein in ColE9 (aa 1-83) |
|
VAng-Lsx02228-50gEcoli |
Creative Biolabs |
50 µg (E. coli) |
EUR 1627.2 |
|
Description: Escherichia coli Colicin-E5 immunity protein in ColE9, recombinant protein. |
 Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-1mg |
|
QP6236-ec-1mg |
EnQuireBio |
1mg |
EUR 1958.4 |
 Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-100ug |
|
QP6236-ec-100ug |
EnQuireBio |
100ug |
EUR 489.6 |
 Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-10ug |
|
QP6236-ec-10ug |
EnQuireBio |
10ug |
EUR 240 |
 Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-200ug |
|
QP6236-ec-200ug |
EnQuireBio |
200ug |
EUR 760.8 |
 Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-500ug |
|
QP6236-ec-500ug |
EnQuireBio |
500ug |
EUR 1272 |
 Recombinant Human Immunity-related GTPase family M protein Protein, GST, E.coli-50ug |
|
QP6236-ec-50ug |
EnQuireBio |
50ug |
EUR 315.6 |
 Antibody) Immunity Related GTPase M (IRGM) Antibody |
|
abx412110-01mg |
Abbexa |
0.1 mg |
EUR 644.4 |
|
|
Immunity Related GTPase M (IRGM) Antibody |
|
abx412110-100tests |
Abbexa |
100 tests |
EUR 537.5 |
) Recombinant Immunoglobulin Transcription Factor 1 (ITF1) |
|
RPE860Mu01 |
Cloud-Clone |
10ug |
EUR 140 |
Recombinant Immunoglobulin Transcription Factor 1 (ITF1) |
|
RPU57336-100ug |
Biomatik Corporation |
100ug |
EUR 470.4 |
Recombinant Immunoglobulin Transcription Factor 1 (ITF1) |
|
RPU57336-1mg |
Biomatik Corporation |
1mg |
EUR 2184 |
Recombinant Immunoglobulin Transcription Factor 1 (ITF1) |
|
RPU57336-50ug |
Biomatik Corporation |
50ug |
EUR 385 |
) Human Immunity-related GTPase family M protein (IRGM) |
|
1-CSB-EP011827HU |
Cusabio |
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
|
|
Description: Recombinant Human Immunity-related GTPase family M protein(IRGM) expressed in E.coli |
 Human INAVA / Innate immunity activator protein ELISA Kit |
|
E4998h |
EIAab |
96T |
EUR 736 |
 Protein) Immunity-Related GTPase Family M Protein (IRGM) Protein |
|
20-abx260986 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
|
|
|
|
Immunity-Related GTPase Family M Protein (IRGM) Protein |
|
abx260986-10g |
Abbexa |
10 µg |
EUR 325 |
Immunity-Related GTPase Family M Protein (IRGM) Protein |
|
abx260986-2g |
Abbexa |
2 µg |
EUR 225 |
 Antibody) Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
20-abx321743 |
Abbexa |
-
Ask for price
-
Ask for price
|
|
|
|
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
20-abx339551 |
Abbexa |
-
Ask for price
-
Ask for price
|
|
|
|
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
abx448534-100ug |
Abbexa |
100 ug |
EUR 627.6 |
|
|
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
20-abx210849 |
Abbexa |
-
Ask for price
-
Ask for price
|
|
|
|
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
20-abx126951 |
Abbexa |
-
Ask for price
-
Ask for price
|
|
|
|
 Antibody) Immunity-Related GTPase Family Q Protein (IRGQ) Antibody |
|
abx234399-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
|
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
abx026104-400ul |
Abbexa |
400 ul |
EUR 627.6 |
|
|
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
abx026104-80l |
Abbexa |
80 µl |
EUR 343.2 |
|
|
Immunity-Related GTPase Family Q Protein (IRGQ) Antibody |
|
abx032348-400ul |
Abbexa |
400 ul |
EUR 661.2 |
|
|
Immunity-Related GTPase Family Q Protein (IRGQ) Antibody |
|
abx032348-80l |
Abbexa |
80 µl |
EUR 385.2 |
|
|
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
abx026104-400l |
Abbexa |
400 µl |
EUR 518.75 |
Immunity-Related GTPase Family Q Protein (IRGQ) Antibody |
|
abx234399-100g |
Abbexa |
100 µg |
EUR 350 |
Immunity-Related GTPase Family Q Protein (IRGQ) Antibody |
|
abx032348-400l |
Abbexa |
400 µl |
EUR 518.75 |
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
abx210849-100l |
Abbexa |
100 µl |
EUR 350 |
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
abx210849-50l |
Abbexa |
50 µl |
EUR 250 |
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
abx321743-100g |
Abbexa |
100 µg |
EUR 350 |
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
abx321743-50g |
Abbexa |
50 µg |
EUR 237.5 |
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
abx339551-100l |
Abbexa |
100 µl |
EUR 350 |
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
abx339551-50l |
Abbexa |
50 µl |
EUR 250 |
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
abx448534-1096tests |
Abbexa |
10 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
abx448534-596tests |
Abbexa |
5 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody |
|
abx448534-96tests |
Abbexa |
96 tests |
EUR 550 |
) Recombinant Progesterone Immunomodulatory Binding Factor 1 (PIBF1) |
|
RPU52494-100ug |
Biomatik Corporation |
100ug |
EUR 528 |
Recombinant Progesterone Immunomodulatory Binding Factor 1 (PIBF1) |
|
RPU52494-1mg |
Biomatik Corporation |
1mg |
EUR 2337.4 |
Recombinant Progesterone Immunomodulatory Binding Factor 1 (PIBF1) |
|
RPU52494-50ug |
Biomatik Corporation |
50ug |
EUR 423.5 |
Recombinant Progesterone Immunomodulatory Binding Factor 1 (PIBF1) |
|
RPN433Hu01 |
Cloud-Clone |
10ug |
EUR 171 |
Recombinant Progesterone Immunomodulatory Binding Factor 1 (PIBF1) |
|
4-RPN433Hu01 |
Cloud-Clone |
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
|
|
Description: Recombinant Human Progesterone Immunomodulatory Binding Factor 1 expressed in: E.coli |
 Antibody (PE)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (PE) |
|
abx448012-1096tests |
Abbexa |
10 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (PE) |
|
abx448012-596tests |
Abbexa |
5 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (PE) |
|
abx448012-96tests |
Abbexa |
96 tests |
EUR 612.5 |
 Antibody (ALP)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (ALP) |
|
abx448005-100ug |
Abbexa |
100 ug |
EUR 693.6 |
|
|
 Antibody (APC)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (APC) |
|
abx448006-100ug |
Abbexa |
100 ug |
EUR 693.6 |
|
|
 Antibody (HRP)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (HRP) |
|
abx448009-100ug |
Abbexa |
100 ug |
EUR 678 |
|
|
 Antibody (RPE)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (RPE) |
|
abx448012-100ug |
Abbexa |
100 ug |
EUR 693.6 |
|
|
Immunity-Related GTPase Family M Protein (IRGM) Antibody (APC) |
|
abx448006-1096tests |
Abbexa |
10 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (APC) |
|
abx448006-596tests |
Abbexa |
5 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (APC) |
|
abx448006-96tests |
Abbexa |
96 tests |
EUR 612.5 |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (HRP) |
|
abx448009-1096tests |
Abbexa |
10 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (HRP) |
|
abx448009-596tests |
Abbexa |
5 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (HRP) |
|
abx448009-96tests |
Abbexa |
96 tests |
EUR 600 |
 Rat Immunity- related GTPase family M protein, Irgm ELISA KIT |
|
ELI-20422r |
Lifescience Market |
96 Tests |
EUR 1063.2 |
 Antibody (FITC)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (FITC) |
|
abx448008-100ug |
Abbexa |
100 ug |
EUR 678 |
|
|
Immunity-Related GTPase Family M Protein (IRGM) Antibody (FITC) |
|
abx448008-1096tests |
Abbexa |
10 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (FITC) |
|
abx448008-596tests |
Abbexa |
5 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (FITC) |
|
abx448008-96tests |
Abbexa |
96 tests |
EUR 600 |
 Antibody (PerCP)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (PerCP) |
|
abx448011-100ug |
Abbexa |
100 ug |
EUR 693.6 |
|
|
Immunity-Related GTPase Family M Protein (IRGM) Antibody (PerCP) |
|
abx448011-1096tests |
Abbexa |
10 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (PerCP) |
|
abx448011-596tests |
Abbexa |
5 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (PerCP) |
|
abx448011-96tests |
Abbexa |
96 tests |
EUR 612.5 |
 Human Immunity- related GTPase family M protein, IRGM ELISA KIT |
|
ELI-48787h |
Lifescience Market |
96 Tests |
EUR 988.8 |
 Mouse Immunity- related GTPase family Q protein, Irgq ELISA KIT |
|
ELI-48788m |
Lifescience Market |
96 Tests |
EUR 1038 |
 Human Immunity- related GTPase family Q protein, IRGQ ELISA KIT |
|
ELI-13087h |
Lifescience Market |
96 Tests |
EUR 988.8 |
 CLIA Kit) Rat Low Density Lipoprotein Immunity Complex (LDL-IC) CLIA Kit |
|
abx197236-96tests |
Abbexa |
96 tests |
EUR 990 |
|
|
 ELISA Kit) Rat Immunity-Related GTPase Family M Protein (IRGM) ELISA Kit |
|
abx528647-96tests |
Abbexa |
96 tests |
EUR 687.5 |
 Antibody (Biotin)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (Biotin) |
|
abx448007-100ug |
Abbexa |
100 ug |
EUR 693.6 |
|
|
Immunity-Related GTPase Family M Protein (IRGM) Antibody (Biotin) |
|
abx448007-1096tests |
Abbexa |
10 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (Biotin) |
|
abx448007-596tests |
Abbexa |
5 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (Biotin) |
|
abx448007-96tests |
Abbexa |
96 tests |
EUR 600 |
 Antibody (ATTO390)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO390) |
|
abx447997-1096tests |
Abbexa |
10 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO390) |
|
abx447997-596tests |
Abbexa |
5 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO390) |
|
abx447997-96tests |
Abbexa |
96 tests |
EUR 612.5 |
 Antibody (ATTO488)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO488) |
|
abx447998-1096tests |
Abbexa |
10 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO488) |
|
abx447998-596tests |
Abbexa |
5 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO488) |
|
abx447998-96tests |
Abbexa |
96 tests |
EUR 612.5 |
 Antibody (ATTO594)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO594) |
|
abx448000-1096tests |
Abbexa |
10 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO594) |
|
abx448000-596tests |
Abbexa |
5 × 96 tests |
Ask for price |
Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO594) |
|
abx448000-96tests |
Abbexa |
96 tests |
EUR 612.5 |
 ELISA Kit) Human Immunity-Related GTPase Family Q Protein (IRGQ) ELISA Kit |
|
abx388031-96tests |
Abbexa |
96 tests |
EUR 1093.2 |
|
|
 ELISA Kit) Human Immunity-related GTPase family M protein (IRGM) ELISA Kit |
|
abx528646-96tests |
Abbexa |
96 tests |
EUR 687.5 |
 ELISA Kit) Mouse Immunity-related GTPase family Q protein (IRGQ) ELISA Kit |
|
abx528650-96tests |
Abbexa |
96 tests |
EUR 687.5 |
 Antibody (ATTO 390)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 390) |
|
abx447997-100ug |
Abbexa |
100 ug |
EUR 693.6 |
|
|
 Antibody (ATTO 488)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 488) |
|
abx447998-100ug |
Abbexa |
100 ug |
EUR 693.6 |
|
|
 Antibody (ATTO 565)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 565) |
|
abx447999-100ug |
Abbexa |
100 ug |
EUR 693.6 |
|
|
 Antibody (ATTO 594)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 594) |
|
abx448000-100ug |
Abbexa |
100 ug |
EUR 693.6 |
|
|
 Antibody (ATTO 633)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 633) |
|
abx448001-100ug |
Abbexa |
100 ug |
EUR 693.6 |
|
|
 Antibody (ATTO 655)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 655) |
|
abx448002-100ug |
Abbexa |
100 ug |
EUR 693.6 |
|
|
 Antibody (ATTO 680)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 680) |
|
abx448003-100ug |
Abbexa |
100 ug |
EUR 693.6 |
|
|
 Antibody (ATTO 700)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (ATTO 700) |
|
abx448004-100ug |
Abbexa |
100 ug |
EUR 693.6 |
|
|
 - Mouse immunity-related GTPase family, Q (Irgq), (10ug)) Irgq (untagged) - Mouse immunity-related GTPase family, Q (Irgq), (10ug) |
|
MC219334 |
Origene Technologies GmbH |
10 µg |
Ask for price |
 Mouse Immunity- related GTPase family M protein 1, Irgm1 ELISA K |
|
ELI-43703m |
Lifescience Market |
96 Tests |
EUR 1038 |
) CLIA kit for Rat LDL-IC (Low Density Lipoprotein Immunity Complex) |
|
E-CL-R0415 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 700.8 |
|
|
|
Description: A sandwich CLIA kit for quantitative measurement of Rat LDL-IC (Low Density Lipoprotein Immunity Complex) in samples from Serum, Plasma, Cell supernatant |
 LDL-IC ELISA Kit| Rat Low Density Lipoprotein Immunity Complex E |
|
EF017860 |
Lifescience Market |
96 Tests |
EUR 826.8 |
) ELISA kit for Rat LDL-IC (Low Density Lipoprotein Immunity Complex) |
|
E-EL-R0581 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 640.8 |
|
|
|
Description: A sandwich ELISA kit for quantitative measurement of Rat LDL-IC (Low Density Lipoprotein Immunity Complex) in samples from Serum, Plasma, Cell supernatant |
 - Human immunity-related GTPase family, cinema (IRGC)) IRGC (GFP-tagged) - Human immunity-related GTPase family, cinema (IRGC) |
|
RG209793 |
Origene Technologies GmbH |
10 µg |
Ask for price |
 Antibody (Streptavidin)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (Streptavidin) |
|
abx448013-100ug |
Abbexa |
100 ug |
EUR 693.6 |
|
|
) Recombinant Nuclear Factor I/A (NFIA) |
|
RPC655Hu01 |
Cloud-Clone |
10ug |
EUR 160 |
Recombinant Nuclear Factor I/A (NFIA) |
|
4-RPC655Hu01 |
Cloud-Clone |
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
|
|
Description: Recombinant Human Nuclear Factor I/A expressed in: E.coli |
 Recombinant Human Transcription Factor-A |
|
7-06637 |
CHI Scientific |
1µg |
Ask for price |
Recombinant Human Transcription Factor-A |
|
7-06638 |
CHI Scientific |
5µg |
Ask for price |
Recombinant Human Transcription Factor-A |
|
7-06639 |
CHI Scientific |
50µg |
Ask for price |
 Transcription Factor-A Recombinant Human |
|
rAP-3757 |
Angio Proteomie |
Inquiry |
Ask for price |
 Antibody (PE/ATTO 594)) Immunity-Related GTPase Family M Protein (IRGM) Antibody (PE/ATTO 594) |
|
abx448010-100ug |
Abbexa |
100 ug |
EUR 710.4 |
|
|
 ELISA Kit) Mouse Immunity-related GTPase family M protein 1 (IRGM1) ELISA Kit |
|
abx528648-96tests |
Abbexa |
96 tests |
EUR 687.5 |
 - Rat immunity-related GTPase family, M (Irgm), (10 ug)) Irgm (untagged ORF) - Rat immunity-related GTPase family, M (Irgm), (10 ug) |
|
RN208492 |
Origene Technologies GmbH |
10 µg |
Ask for price |
 - Rat immunity-related GTPase family, Q (Irgq), (10 ug)) Irgq (untagged ORF) - Rat immunity-related GTPase family, Q (Irgq), (10 ug) |
|
RN205706 |
Origene Technologies GmbH |
10 µg |
Ask for price |
 - Mouse immunity-related GTPase family, Q (Irgq)) Irgq (Myc-DDK-tagged) - Mouse immunity-related GTPase family, Q (Irgq) |
|
MR209126 |
Origene Technologies GmbH |
10 µg |
Ask for price |
While numerous advances have been made to mitigate this difficulty, together with the usage of chemical substances, excisable and non-integrating vectors, and use of the modified mRNA, security stays a priority. Both integrating and non-integrating strategies additionally endure from many different limitations together with low effectivity, variability, and tumorigenicity.
The non-integrating mRNA reprogramming is of excessive effectivity, however it’s delicate to reagents and want approaches to cut back the immunogenic response. An various non-integrating and safer approach of producing iPSCs is through direct supply of recombinant cell-penetrating reprogramming proteins into the cells to be reprogrammed, however reprogramming effectivity of the protein-based strategy is extraordinarily low in comparison with the traditional virus-based nuclear reprogramming. Herein, we describe detailed steps for environment friendly era of human iPSCs by protein-based reprogramming in mixture with stimulation of the Toll-like receptor 3 (TLR3) innate immune pathway.
